Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1D1 | P20393 | 12/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.38 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8528925 | 1.00 | NR1D1 (0.48) | NR1D1NR1H3MAPTMEN1KMT2A | |
| SCHEMBL8421694 | 0.84 | MAPT (0.48) | NR1D1NR1H3MAPTMEN1KMT2A | |
| SCHEMBL8421691 | 0.84 | MAPT (0.48) | NR1D1NR1H3MAPTMEN1KMT2A | |
| SCHEMBL8527555 | 0.81 | MAPT (0.48) | NR1D1NR1H3MAPTMEN1KMT2A | |
| SCHEMBL8527559 | 0.81 | MAPT (0.48) | NR1D1NR1H3MAPTMEN1KMT2A | |
| SCHEMBL8423297 | 0.76 | MAPT (0.46) | NR1D1NR1H3MAPTMEN1KMT2A | |
| SCHEMBL8423298 | 0.76 | MAPT (0.46) | NR1D1NR1H3MAPTMEN1KMT2A | |
| SCHEMBL8251477 | 0.75 | ITGA4 (0.49) | NR1D1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL2502338 | 0.75 | ITGA4 (0.49) | NR1D1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL5769414 | 0.74 | KMT2A (0.48) | NR1D1NR1H3MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705257-B1 | AMINOACID DERIVATIVES AS NO SYNTHASE INHIBITORS | WELLCOME FOUND (GB) | 1998-03-11 | — | — | EP | disclosed |
| EP-0705257-A1 | AMINOACID DERIVATIVES AS NO SYNTHASE INHIBITORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-04-10 | — | — | EP | disclosed |
| WO-1995000505-A1 | AMINOACID DERIVATIVES AS NO SYNTHASE INHIBITORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-01-05 | — | — | WO | disclosed |