Sugi Predict

Sugi Predict / Compounds / SCHEMBL8527666

SCHEMBL8527666

SCHEMBL8527666

CC(C)(C)OC(=O)c1c(OCc2ccccc2)ccn2ncnc12

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SMN1; SMN2 Q16637 2/20 0.38
▸ POLB P06746 1/20 0.38
▸ BRD4 O60885 1/20 0.38
▸ KDM4E B2RXH2 3/20 0.38
▸ ALDH1A1 P00352 3/20 0.38
▸ GAA P10253 3/20 0.38
▸ MAPT P10636 3/20 0.38
▸ HPGD P15428 3/20 0.38
▸ GLA P06280 2/20 0.38
▸ HIF1A Q16665 2/20 0.38
▸ THRB P10828 1/20 0.38
▸ ATP4A P20648 2/20 0.37
▸ ATP4B P51164 2/20 0.37
▸ DAPK1 P53355 1/20 0.36
▸ CYP2C9 P11712 1/20 0.36
▸ PTGER1 P34995 1/20 0.36
▸ MAPK14 Q16539 3/20 0.36
▸ RXRA P19793 1/20 0.36
▸ RXRB P28702 1/20 0.36
▸ RXRG P48443 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12750410 0.85 PPIA (0.44) SMN1; SMN2POLBKDM4EALDH1A1GAA
SCHEMBL8527782 0.81 CYP2C9 (0.37) SMN1; SMN2POLBBRD4KDM4EALDH1A1
SCHEMBL30599275 0.79 ELANE (0.34) SMN1; SMN2BRD4KDM4EALDH1A1GAA
SCHEMBL12750362 0.79 BRD4 (0.38) SMN1; SMN2POLBBRD4KDM4EALDH1A1
SCHEMBL8526969 0.79 EGLN2 (0.39) BRD4KDM4EALDH1A1GAAMAPT
SCHEMBL30599272 0.77 PPARG (0.36) BRD4KDM4EALDH1A1GAAMAPT
SCHEMBL30599269 0.77 ALDH1A1 (0.36) SMN1; SMN2KDM4EALDH1A1GAAMAPT
SCHEMBL12750386 0.76 ADORA3 (0.35) SMN1; SMN2POLBBRD4KDM4EALDH1A1
SCHEMBL8517633 0.76 PTGER1 (0.41) KDM4EALDH1A1GAAMAPTHPGD
SCHEMBL29842452 0.75 BRD4 (0.40) SMN1; SMN2POLBBRD4ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4578855-A1 PROLYL HYDROXYLASE INHIBITOR AND USE THEREOF Suzhong Pharmaceutical Group Co., Ltd. (CN) 2025-07-02 — — EP disclosed
CN-119948024-A Prolyl hydroxylase inhibitor and application thereof 苏中药业集团股份有限公司 2025-05-06 — — CN disclosed
CN-116496269-B Prolyl hydroxylase inhibitor and application thereof 苏中药业集团股份有限公司 2025-02-28 — — CN disclosed
CN-116496269-A Prolyl hydroxylase inhibitor and application thereof 苏中药业集团股份有限公司 2023-07-28 — — CN disclosed
US-20160145254-A1 TRIAZOLOPYRIDINE COMPOUND, AND ACTION THEREOF AS PROLYL HYDROXYLASE INHIBITOR OR ERYTHROPOIETIN PRODUCTION-INDUCING AGENT JAPAN TOBACCO INC. (JP) 2016-05-26 — — US disclosed
US-20160145254-A1 TRIAZOLOPYRIDINE COMPOUND, AND ACTION THEREOF AS PROLYL HYDROXYLASE INHIBITOR OR ERYTHROPOIETIN PRODUCTION-INDUCING AGENT JAPAN TOBACCO INC. (JP) 2016-05-26 — — US disclosed
EP-2455381-B9 TRIAZOLOPYRIDINE COMPOUND, AND ACTION THEREOF AS PROLYL HYDROXYLASE INHIBITOR AND ERYTHROPOIETIN PRODUCTION INDUCER JAPAN TOBACCO INC (JP) 2014-10-22 — — EP disclosed
EP-2455381-B1 TRIAZOLOPYRIDINE COMPOUND, AND ACTION THEREOF AS PROLYL HYDROXYLASE INHIBITOR AND ERYTHROPOIETIN PRODUCTION INDUCER JAPAN TOBACCO INC (JP) 2014-05-28 — — EP disclosed
US-20130096155-A1 TRIAZOLOPYRIDINE COMPOUND, AND ACTION THEREOF AS PROLYL HYDROXYLASE INHIBITOR OR ERYTHROPOIETIN PRODUCTION-INDUCING AGENT JAPAN TOBACCO INC. (JP) 2013-04-18 — — US disclosed
US-20130096155-A1 TRIAZOLOPYRIDINE COMPOUND, AND ACTION THEREOF AS PROLYL HYDROXYLASE INHIBITOR OR ERYTHROPOIETIN PRODUCTION-INDUCING AGENT JAPAN TOBACCO INC. (JP) 2013-04-18 — — US disclosed
US-8283465-B2 Triazolopyridine compound, and action thereof as prolyl hydroxylase inhibitor or erythropoietin production-inducing agent JAPAN TOBACCO INC. (JP) 2012-10-09 — — US disclosed
US-8283465-B2 Triazolopyridine compound, and action thereof as prolyl hydroxylase inhibitor or erythropoietin production-inducing agent JAPAN TOBACCO INC. (JP) 2012-10-09 — — US disclosed
EP-2455381-A1 TRIAZOLOPYRIDINE COMPOUND, AND ACTION THEREOF AS PROLYL HYDROXYLASE INHIBITOR AND ERYTHROPOIETIN PRODUCTION INDUCER Japan Tobacco, Inc. (JP) 2012-05-23 — — EP disclosed
US-20110077267-A1 TRIAZOLOPYRIDINE COMPOUND, AND ACTION THEREOF AS PROLYL HYDROXYLASE INHIBITOR OR ERYTHROPOIETIN PRODUCTION-INDUCING AGENT JAPAN TOBACCO INC. (JP) 2011-03-31 — — US disclosed
US-20110077267-A1 TRIAZOLOPYRIDINE COMPOUND, AND ACTION THEREOF AS PROLYL HYDROXYLASE INHIBITOR OR ERYTHROPOIETIN PRODUCTION-INDUCING AGENT JAPAN TOBACCO INC. (JP) 2011-03-31 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130096155-A1 TRIAZOLOPYRIDINE COMPOUND, AND ACTION THEREOF AS PROLYL HYDROXYLASE INHIBITOR OR ERYTHROPOIETIN PRODUCTION-INDUCING AGENT EGLN3, EPOR, EGLN2 SMN1; SMN2 2585/4885POLB 2476/4885BRD4 1848/4885
US-20110077267-A1 TRIAZOLOPYRIDINE COMPOUND, AND ACTION THEREOF AS PROLYL HYDROXYLASE INHIBITOR OR ERYTHROPOIETIN PRODUCTION-INDUCING AGENT EGLN3, EPOR, EGLN2 SMN1; SMN2 2585/4885POLB 2476/4885BRD4 1848/4885
US-20160145254-A1 TRIAZOLOPYRIDINE COMPOUND, AND ACTION THEREOF AS PROLYL HYDROXYLASE INHIBITOR OR ERYTHROPOIETIN PRODUCTION-INDUCING AGENT EGLN3, EPOR, EGLN2 SMN1; SMN2 2585/4885POLB 2476/4885BRD4 1848/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.