SCHEMBL8527738

SCHEMBL8527738

CCSc1cc2c(cc1Br)NCC2

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.42
MAPT P10636 2/20 0.42
SMN1; SMN2 Q16637 1/20 0.35
DRD2 P14416 1/20 0.35
DRD4 P21917 1/20 0.35
KDM4E B2RXH2 1/20 0.31
LMNA P02545 1/20 0.31
TP53 P04637 1/20 0.31
GAA P10253 1/20 0.31
THRB P10828 1/20 0.31
ALOX15 P16050 1/20 0.31
CASP1 P29466 1/20 0.31
HTT P42858 1/20 0.31
CASP7 P55210 1/20 0.31
HSD17B10 Q99714 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
AR P10275 1/20 0.31
S1PR1 P21453 2/20 0.30
S1PR3 Q99500 1/20 0.30
GFER P55789 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8526682 0.88 ALDH1A1 (0.40) ALDH1A1MAPTSMN1; SMN2DRD2DRD4
SCHEMBL8528753 0.81 ALDH1A1 (0.45) ALDH1A1MAPTSMN1; SMN2DRD2DRD4
SCHEMBL8785768 0.81 ALDH1A1 (0.47) ALDH1A1MAPTSMN1; SMN2DRD2DRD4
SCHEMBL8529844 0.81 DRD2 (0.39) ALDH1A1MAPTSMN1; SMN2DRD2DRD4
SCHEMBL3731583 0.72 ALDH1A1 (0.49) ALDH1A1MAPTSMN1; SMN2DRD2DRD4
SCHEMBL3245294 0.70 DRD2 (0.49) ALDH1A1MAPTSMN1; SMN2DRD2DRD4
SCHEMBL23063842 0.68 ALDH1A1 (0.53) ALDH1A1MAPTSMN1; SMN2DRD2DRD4
SCHEMBL6101285 0.68 ALDH1A1 (0.49) ALDH1A1MAPTSMN1; SMN2DRD2DRD4
SCHEMBL34460094 0.68 ALDH1A1 (0.49) ALDH1A1MAPTSMN1; SMN2DRD2DRD4
SCHEMBL4496862 0.67 DRD2 (0.56) ALDH1A1MAPTSMN1; SMN2DRD2DRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5834494-A SEROTONIN 5HT2B/2C RECEPTOR ANTAGONISTS; CNS NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS; IRRITABLE BOWEL SYNDROME SMITHKLINE BEECHAM P.L.C. (GB) 1998-11-10 US disclosed
EP-0707581-B1 INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1997-02-26 EP disclosed
EP-0707581-A1 INDOLINE DERIVATIVES AS 5HT 2C? ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1996-04-24 EP disclosed
WO-1995001976-A1 INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1995-01-19 WO disclosed