Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 3/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5648992 | 0.71 | NOS2 (0.40) | — | |
| SCHEMBL31150941 | 0.71 | NOS2 (0.40) | — | |
| SCHEMBL21437197 | 0.71 | SMN1; SMN2 (0.38) | NPC1RAB9A | |
| SCHEMBL4402294 | 0.69 | AURKA (0.33) | — | |
| SCHEMBL25650131 | 0.69 | STING1 (0.34) | — | |
| SCHEMBL31437498 | 0.69 | AURKA (0.33) | — | |
| SCHEMBL768723 | 0.68 | NPC1 (0.35) | NPC1RAB9A | |
| SCHEMBL5860931 | 0.68 | MTNR1A (0.30) | — | |
| SCHEMBL23726539 | 0.67 | NPC1 (0.43) | NPC1RAB9A | |
| SCHEMBL2798777 | 0.66 | TXNRD1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946566-A1 | PRO-DRUGS AND COUNTERPARTS OF CAMPTOTHECIN, THEIR APPLICATION AS MEDICINES | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998028304-A1 | PRO-DRUGS AND COUNTERPARTS OF CAMPTOTHECIN, THEIR APPLICATION AS MEDICINES | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 1998-07-02 | — | — | WO | disclosed |