Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 5/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 5/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 5/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 5/20 | 0.33 |
| ▸ | FDPS | P14324 | 2/20 | 0.31 |
| ▸ | ANPEP | P15144 | 2/20 | 0.30 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8531443 | 0.98 | FOLH1 (0.36) | FOLH1METAP1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL5365372 | 0.76 | MMP2 (0.33) | METAP1FDPS | |
| SCHEMBL8532025 | 0.72 | METAP1 (0.41) | FOLH1METAP1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL8868098 | 0.65 | FOLH1 (0.42) | FOLH1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8528123 | 0.65 | ANPEP (0.37) | FOLH1FDPSANPEPERAP2 | |
| SCHEMBL8528278 | 0.64 | FOLH1 (0.41) | FOLH1 | |
| SCHEMBL15873623 | 0.63 | FOLH1 (0.48) | FOLH1 | |
| SCHEMBL2983921 | 0.63 | FOLH1 (0.48) | FOLH1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8529730 | 0.63 | ANPEP (0.35) | FOLH1ANPEPERAP2 | |
| SCHEMBL8528026 | 0.62 | FOLH1 (0.40) | FOLH1FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752999-B1 | 2,4-DIPHOSPHONOGLUTARIC ACID DERIVATIVES, METHODS OF PREPARING SUCH COMPOUNDS AND DRUGS CONTAINING THEM | BOEHRINGER MANNHEIM GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| US-5698541-A | DISEASES OF CALCIUM METABOLISM; OSTEOPOROSIS | BOEHRINGER MANNHEIM GMBH (DE) | 1997-12-16 | — | — | US | disclosed |