SCHEMBL8528296

SCHEMBL8528296

CC(C)c1ccccc1OC(F)(F)C(F)C(F)(F)F

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RECQL P46063 2/20 0.40
AR P10275 1/20 0.39
TSHR P16473 3/20 0.38
ALDH1A1 P00352 2/20 0.38
HSD17B10 Q99714 1/20 0.38
KCNK3 O14649 1/20 0.38
KCNK9 Q9NPC2 1/20 0.38
P2RX3 P56373 1/20 0.35
P2RX2 Q9UBL9 1/20 0.35
GABRA1 P14867 2/20 0.34
GABRB2 P47870 2/20 0.34
KMT2A Q03164 4/20 0.34
MEN1 O00255 3/20 0.34
CYP1A2 P05177 3/20 0.34
CYP2C19 P33261 2/20 0.34
NISCH Q9Y2I1 2/20 0.34
CYP3A4 P08684 2/20 0.34
CYP2C9 P11712 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
ADRA2A P08913 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12868106 0.87 AR (0.41) RECQLARTSHRALDH1A1KCNK3
SCHEMBL26505533 0.86 AR (0.40) RECQLARTSHRALDH1A1KCNK3
SCHEMBL7751671 0.83 ALDH1A1 (0.46) RECQLTSHRALDH1A1HSD17B10KMT2A
SCHEMBL807278 0.80 KCNK3 (0.52) RECQLARTSHRALDH1A1KCNK3
SCHEMBL8526830 0.78 RECQL (0.42) RECQLTSHRALDH1A1HSD17B10KMT2A
SCHEMBL7751907 0.77 ALDH1A1 (0.41) RECQLARTSHRALDH1A1HSD17B10
SCHEMBL9009537 0.76 AR (0.39) RECQLARTSHRALDH1A1KCNK3
SCHEMBL2940314 0.75 ALDH1A1 (0.41) RECQLTSHRALDH1A1HSD17B10KMT2A
SCHEMBL13019851 0.74 CYP3A4 (0.43) RECQLARTSHRALDH1A1KCNK3
SCHEMBL8527588 0.72 RECQL (0.41) RECQLTSHRALDH1A1HSD17B10KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0596358-B1 0-Phenylenediamines containing fluoroakyl(ene) groups and their use as intermediates in the preparation of benzimidazoles BAYER AG (DE) 1998-10-28 EP disclosed
US-5484953-A CHEMICAL INTERMEDIATES FOR BENZIMIDAZOLES FOR INSECTICIDES OR NEMATOCIDES BAYER AKTIENGESELLSCHAFT (DE) 1996-01-16 US disclosed
EP-0596358-A1 0-Phenylenediamines containing fluoroakyl(ene) groups and their use as intermediates in the preparation of benzimidazoles BAYER AG (DE) 1994-05-11 EP disclosed