Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL8038349 | 0.87 | LMNA (0.33) | — | |
| Iodide SCHEMBL8531750 | 0.85 | IDO1 (0.33) | IDO1TDO2 | |
| Iodide SCHEMBL8529133 | 0.71 | TRPA1 (0.33) | — | |
| Iodide SCHEMBL8532159 | 0.70 | HIF1A (0.34) | — | |
| Iodide SCHEMBL8528561 | 0.67 | HIF1A (0.34) | — | |
| Iodide SCHEMBL8531789 | 0.66 | HIF1A (0.33) | — | |
| Iodide SCHEMBL9850852 | 0.66 | HIF1A (0.33) | — | |
| Iodide SCHEMBL8528705 | 0.65 | HIF1A (0.38) | — | |
| Iodide SCHEMBL8529368 | 0.64 | ACP3 (0.38) | MAPTKMT2ACNR2 | |
| Iodide SCHEMBL8528209 | 0.62 | HIF1A (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5830875-A | PARASITICIDES | MERCK & CO., INC. (US) | 1998-11-03 | — | — | US | disclosed |
| EP-0428286-A2 | 24- and 25-substituted avermectin and milbemycin derivatives | MERCK & CO. INC. (US) | 1991-05-22 | — | — | EP | disclosed |