SCHEMBL8528792

SCHEMBL8528792

COc1cc[c]c(-c2ccccc2OC)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.44
SMN1; SMN2 Q16637 3/20 0.44
HPGD P15428 2/20 0.44
AR P10275 1/20 0.43
HDAC4 P56524 1/20 0.42
HDAC2 Q92769 1/20 0.42
HDAC8 Q9BY41 1/20 0.42
APP P05067 1/20 0.42
CYP1A1 P04798 2/20 0.40
CYP1A2 P05177 2/20 0.40
CYP1B1 Q16678 2/20 0.40
CA12 O43570 2/20 0.40
CA1 P00915 2/20 0.40
CA2 P00918 2/20 0.40
CA7 P43166 2/20 0.40
CA9 Q16790 2/20 0.40
CA14 Q9ULX7 2/20 0.40
CA4 P22748 1/20 0.40
TP53 P04637 1/20 0.39
TSHR P16473 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8729761 0.86 GRIN1 (0.43) ALDH1A1SMN1; SMN2HPGDCYP1A2TSHR
SCHEMBL7005116 0.86 NPSR1 (0.46) ARCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL11441732 0.86 APP (0.40) ALDH1A1SMN1; SMN2HPGDAPPTSHR
SCHEMBL6189588 0.84 CYP1A1 (0.51) ALDH1A1SMN1; SMN2HPGDCYP1A1CYP1A2
SCHEMBL4608864 0.83 ALDH1A1 (0.44) ALDH1A1SMN1; SMN2HPGDAPPCA12
SCHEMBL8125196 0.83 CYP1A2 (0.40) ALDH1A1SMN1; SMN2HPGDCYP1A2CA4
SCHEMBL4608507 0.81 HSP90AA1 (0.41) ALDH1A1SMN1; SMN2HPGDAPPCA12
SCHEMBL5670544 0.81 MEN1 (0.40) ALDH1A1SMN1; SMN2CYP1A2TSHRLMNA
SCHEMBL8123605 0.81 RAB9A (0.46) ALDH1A1SMN1; SMN2HPGDCYP1A2TP53
SCHEMBL5497662 0.81 MAPK1 (0.40) ALDH1A1SMN1; SMN2CYP1A1CYP1A2CYP1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118255649-A Samarium diiodide mediated lignin beta-O-4 ketone model compound free radical cleavage 浙江大学 2024-06-28 CN disclosed
US-5749925-A Dyeing or printing process with new and known cationic 4,5-dihydro-iH-1,2,3-triazolium compounds as dyestuffs and new cationic 4,5-dihydro-1H-1,2,3-triazolium compounds BAYER AKTIENGESELLSCHAFT (DE) 1998-05-12 US disclosed
US-4455421-A ANTIFERTILITY, ANTIULCER AGENTS; TETRAZOLE DERIVATIVES PFIZER INC. (US) 1984-06-19 US disclosed
US-4365077-A ANTIFERTILITY, ANTIULCER PFIZER INC. (US) 1982-12-21 US disclosed
US-4157341-A 11-Desoxy-16-aryloxy-ω-tetranorprostaglandins PFIZER INC. (US) 1979-06-05 US disclosed