Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7439619 | 0.80 | LMNA (0.41) | TSHRLMNAKDM4EALDH1A1 | |
| SCHEMBL733970 | 0.80 | ALDH1A1 (0.48) | TSHRLMNAALDH1A1MAPT | |
| SCHEMBL9095817 | 0.77 | LMNA (0.52) | TSHRKMT2AMEN1LMNAALDH1A1 | |
| Dimethyl Succinate SCHEMBL10213 | 0.75 | TSHR (1.00) | TSHRKMT2AMEN1LMNAKDM4E | |
| Dimethyl Succinate SCHEMBL28054469 | 0.75 | TSHR (1.00) | TSHRKMT2AMEN1LMNAKDM4E | |
| SCHEMBL8154447 | 0.75 | LMNA (0.60) | TSHRKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL8527984 | 0.75 | CYP2C9 (0.38) | KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL1979159 | 0.75 | TSHR (0.65) | TSHRKMT2AMEN1LMNAKDM4E | |
| SCHEMBL7735643 | 0.74 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL3216541 | 0.74 | LMNA (0.63) | TSHRKMT2AMEN1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821236-A | Tumor treatment with arabinofuranosyl purine derivatives | GLAXO WELLCOME INC. (US) | 1998-10-13 | — | — | US | disclosed |
| US-5747472-A | ANTICARCINOGENIC AGENTS AND ANTITUMOR AGENTS | GLAXO WELLCOME INC. (US) | 1998-05-05 | — | — | US | disclosed |
| EP-0539479-B1 | HETEROCYCLIC COMPOUNDS | WELLCOME FOUND (GB) | 1997-04-16 | — | — | EP | disclosed |
| US-5492897-A | ANTITUMOR AGENTS, AUTOIMMUNE DISEASES | BURROUGHS WELLCOME CO. (141) (US) | 1996-02-20 | — | — | US | disclosed |
| EP-0539479-A1 | HETEROCYCLIC COMPOUNDS. | WELLCOME FOUND (GB) | 1993-05-05 | — | — | EP | disclosed |
| WO-1992001456-A1 | HETEROCYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-02-06 | — | — | WO | disclosed |