Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HTR7 | P34969 | 2/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31571584 | 0.89 | GPR84 (0.68) | GPR84NPC1KDM4EHTR7HTR6 | |
| SCHEMBL27142546 | 0.89 | GPR84 (0.68) | GPR84NPC1KDM4EHTR7HTR6 | |
| SCHEMBL29871648 | 0.87 | GPR84 (0.87) | GPR84NPC1KDM4EHTR7HTR6 | |
| SCHEMBL22554662 | 0.87 | GPR84 (0.73) | GPR84NPC1KDM4EHTR7HTR6 | |
| SCHEMBL2161423 | 0.86 | GPR84 (0.76) | GPR84NPC1KDM4EHTR7HTR6 | |
| SCHEMBL2161735 | 0.84 | GPR84 (0.70) | GPR84NPC1KDM4EHTR7HTR6 | |
| SCHEMBL3974212 | 0.83 | NPC1 (0.80) | GPR84NPC1KDM4EHTR7HTR6 | |
| SCHEMBL10174674 | 0.83 | HTR1D (0.56) | GPR84KDM4EHTR1AHTR1DHTR1B | |
| SCHEMBL12844152 | 0.83 | GPR84 (0.68) | GPR84NPC1HTR7HTR6KMT2A | |
| SCHEMBL853729 | 0.83 | NPSR1 (0.68) | KDM4EHTR7HTR6KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0489547-B1 | A process for the preparation of a 3-alkylated indole, intermediates, and a process for the preparation of a derivative thereof | ZENECA LTD (GB) | 1998-07-29 | — | — | EP | disclosed |
| US-5280125-A | Chemical process for the preparation of 3-alkylated indole | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-01-18 | — | — | US | disclosed |
| EP-0489547-A1 | A process for the preparation of a 3-alkylated indole, intermediates, and a process for the preparation of a derivative thereof | ZENECA LIMITED (GB) | 1992-06-10 | — | — | EP | disclosed |