Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 4/20 | 0.38 |
| ▸ | CA9 | Q16790 | 4/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6514943 | 0.86 | LMNA (0.43) | LMNAHTTSMN1; SMN2RECQLCYP3A4 | |
| SCHEMBL2943216 | 0.85 | LMNA (0.43) | LMNAHTTSMN1; SMN2RECQLCYP3A4 | |
| SCHEMBL28502449 | 0.82 | LMNA (0.42) | LMNAHTTSMN1; SMN2CYP3A4CYP2D6 | |
| SCHEMBL9131821 | 0.81 | GAA (0.43) | LMNAHTTSMN1; SMN2CYP3A4CYP2D6 | |
| SCHEMBL4303539 | 0.81 | SMN1; SMN2 (0.40) | LMNAHTTSMN1; SMN2RECQLCYP3A4 | |
| SCHEMBL8863313 | 0.81 | ALDH1A1 (0.55) | LMNAHTTSMN1; SMN2CYP3A4CYP2D6 | |
| SCHEMBL2638736 | 0.80 | HTT (0.49) | LMNAHTTSMN1; SMN2MAPK1ACHE | |
| SCHEMBL11150598 | 0.80 | C5AR1 (0.41) | LMNAHTTSMN1; SMN2RECQLCYP3A4 | |
| SCHEMBL17847866 | 0.80 | HSP90AA1 (0.44) | LMNAHTTSMN1; SMN2RECQLCYP3A4 | |
| SCHEMBL1982598 | 0.79 | TERT (0.49) | LMNAHTTSMN1; SMN2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5362859-A | Immobilized ligand proteins, chromatography | SEPRACOR, INC. (US) | 1994-11-08 | — | — | US | claimed |
| EP-0610755-A1 | An affinity separation device and its use for immunoglobulin separation | Pall Corporation (US) | 1994-08-17 | — | — | EP | claimed |
| EP-0433112-B1 | Modified gangliosides and the functional derivatives thereof | FIDIA SPA (IT) | 1998-10-28 | — | — | EP | disclosed |
| US-5424294-A | Treating central and peripheral nervous system disorders | FIDIA S.P.A. (IT) | 1995-06-13 | — | — | US | disclosed |
| US-5362859-A | Immobilized ligand proteins, chromatography | SEPRACOR, INC. (US) | 1994-11-08 | — | — | US | disclosed |
| EP-0611592-A2 | Membranes for use in affinity separation and methods for activating membranes | Pall Corporation (US) | 1994-08-24 | — | — | EP | disclosed |
| EP-0610755-A1 | An affinity separation device and its use for immunoglobulin separation | Pall Corporation (US) | 1994-08-17 | — | — | EP | disclosed |
| EP-0610756-A1 | Activated membrane and method for ligate separation | Pall Corporation (US) | 1994-08-17 | — | — | EP | disclosed |
| US-5310688-A | Chromatography | SEPRACOR INC. (US) | 1994-05-10 | — | — | US | disclosed |
| US-5264424-A | Modified gangliosides and the functional derivatives thereof | FIDIA S.P.A. (IT) | 1993-11-23 | — | — | US | disclosed |
| EP-0433112-A1 | Modified gangliosides and the functional derivatives thereof | FIDIA S.p.A. (IT) | 1991-06-19 | — | — | EP | disclosed |