Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.61 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.61 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.61 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4544356 | 0.87 | ALDH1A1 (0.57) | ADORA3ADORA2AADORA1ADORA2BTSHR | |
| SCHEMBL12429197 | 0.81 | TEAD2 (0.45) | ADORA3ADORA2AADORA1ADORA2BTSHR | |
| SCHEMBL175330 | 0.80 | ALDH1A1 (0.46) | ADORA3ADORA2AADORA1TSHRSMN1; SMN2 | |
| SCHEMBL31714887 | 0.79 | TEAD2 (0.43) | ADORA3ADORA2AADORA1ADORA2BTSHR | |
| SCHEMBL15884432 | 0.79 | TEAD2 (0.48) | ADORA3ADORA2AADORA1ADORA2BTSHR | |
| SCHEMBL2079861 | 0.76 | NPSR1 (0.64) | ADORA2AADORA1TSHRSMN1; SMN2MAPT | |
| SCHEMBL645045 | 0.76 | ADORA3 (0.54) | ADORA3ADORA2AADORA1TSHRSMN1; SMN2 | |
| SCHEMBL31715177 | 0.76 | ALDH1A1 (0.43) | ADORA3ADORA2AADORA1TSHRSMN1; SMN2 | |
| SCHEMBL17785298 | 0.76 | ALDH1A1 (0.45) | ADORA2AADORA1TSHRSMN1; SMN2MAPT | |
| SCHEMBL31352252 | 0.75 | ADORA3 (0.57) | ADORA3ADORA2AADORA1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846991-A | Pyrazole derivatives | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1998-12-08 | — | — | US | disclosed |
| US-5840909-A | Pyrazole derivatives | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1998-11-24 | — | — | US | disclosed |
| US-5817828-A | HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS; VISION DEFECTS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1998-10-06 | — | — | US | disclosed |
| US-5721264-A | EXHIBIT ANTAGONISTIC EFFECT AGAINST ANGIOTENSIN II; USEFUL FOR PREVENTION AND REMEDY OF HYPERTENSION, CONGESTIVE HEARTFAILURE, CHRONIC RENAL INSUFFICIENCY, ALDOSTERONISM | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-24 | — | — | US | disclosed |
| EP-0693480-A1 | PYRAZOLE DERIVATIVE | NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) | 1996-01-24 | — | — | EP | disclosed |