Known targets — ChEMBL curated mechanism
823298382338688239847Rdl1Rdl2Rdl3
The experimentally established mechanism targets of Lindane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.39 |
| ▸ | KDM5C | P41229 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | TLR4 | O00206 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24091 | 0.87 | — | — | |
| SCHEMBL29913539 | 0.85 | — | — | |
| SCHEMBL27658550 | 0.85 | — | — | |
| SCHEMBL28067162 | 0.85 | — | — | |
| SCHEMBL27918442 | 0.85 | — | — | |
| SCHEMBL27612780 | 0.85 | — | — | |
| SCHEMBL28828212 | 0.85 | — | — | |
| SCHEMBL27740018 | 0.85 | — | — | |
| Lindane SCHEMBL10446322 | 0.82 | ALDH1A1 (0.37) | — | |
| Lindane SCHEMBL8746980 | 0.76 | LDHA (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873429-A1 | EXTRACTING METALS DIRECTLY FROM METAL OXIDES | IDAHO RESEARCH FOUNDATION, INC. (US) | 1998-10-28 | — | — | EP | claimed |
| WO-1997016575-A9 | EXTRACTING METALS DIRECTLY FROM METAL OXIDES | — | 1997-08-07 | — | — | WO | claimed |
| WO-1997016575-A1 | EXTRACTING METALS DIRECTLY FROM METAL OXIDES | IDAHO RESEARCH FOUNDATION, INC. (US) | 1997-05-09 | — | — | WO | claimed |