Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 6/20 | 0.43 |
| ▸ | GAA | P10253 | 6/20 | 0.43 |
| ▸ | SI | P14410 | 6/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 6/20 | 0.43 |
| ▸ | LTA4H | P09960 | 4/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | HTR1D | P28221 | 2/20 | 0.38 |
| ▸ | HTR1B | P28222 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL852769 | 0.89 | LTA4H (0.41) | MGAMGAASIMGAM2LTA4H | |
| SCHEMBL6161712 | 0.80 | MGAM (0.42) | MGAMGAASIMGAM2LTA4H | |
| SCHEMBL6694049 | 0.79 | MGAM (0.41) | MGAMGAASIMGAM2LTA4H | |
| SCHEMBL3046460 | 0.77 | ITGB3 (0.57) | — | |
| Trifluoroacetic Acid SCHEMBL6701408 | 0.77 | MTNR1A (0.39) | MGAMGAASIMGAM2LTA4H | |
| SCHEMBL853153 | 0.77 | ITGB3 (0.59) | MTNR1AMTNR1B | |
| SCHEMBL3042341 | 0.76 | ITGB3 (0.54) | — | |
| SCHEMBL6166093 | 0.76 | MGAM (0.47) | MGAMGAASIMGAM2 | |
| Trifluoroacetic Acid SCHEMBL6694022 | 0.75 | MTNR1A (0.38) | MGAMGAASIMGAM2MTNR1A | |
| SCHEMBL853227 | 0.75 | MGAM (0.44) | MGAMGAASIMGAM2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425010-B8 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | JANSSEN PHARMACEUTICALS INC (US) | 2012-03-28 | — | — | EP | disclosed |
| EP-1425010-A4 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | ORTHO MCNEIL PHARM INC (US) | 2009-07-29 | — | — | EP | disclosed |
| EP-1425010-A1 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2004-06-09 | — | — | EP | disclosed |
| WO-2002060438-A1 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2002-08-08 | — | — | WO | disclosed |