Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 5/20 | 0.37 |
| ▸ | GRIK2 | Q13002 | 5/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8531395 | 0.78 | CYP2D6 (0.61) | GRIK1GRIK2SLC1A2SLC1A1SLC1A3 | |
| SCHEMBL8531394 | 0.78 | CYP2D6 (0.61) | GRIK1GRIK2SLC1A2SLC1A1SLC1A3 | |
| SCHEMBL10915178 | 0.78 | CYP2D6 (0.61) | GRIK1GRIK2SLC1A2SLC1A1SLC1A3 | |
| SCHEMBL9635488 | 0.76 | GSR (0.43) | GRIK1GRIK2SLC1A2SLC1A1SLC1A3 | |
| Hydrochloric Acid SCHEMBL10963195 | 0.76 | CYP2D6 (0.59) | GRIK1GRIK2SLC1A2SLC1A1SLC1A3 | |
| Hydrochloric Acid SCHEMBL10963186 | 0.76 | CYP2D6 (0.59) | GRIK1GRIK2SLC1A2SLC1A1SLC1A3 | |
| SCHEMBL8535890 | 0.74 | NFKB1 (0.47) | GRIK1GRIK2SLC1A2SLC1A1SLC1A3 | |
| SCHEMBL8021322 | 0.73 | CHRM1 (0.43) | GRIK1GRIK2SLC1A2SLC1A1SLC1A3 | |
| SCHEMBL28755597 | 0.73 | OPRM1 (0.43) | BLMCYP2D6CYP3A4 | |
| SCHEMBL28700382 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705240-B1 | NOVEL PROCESSES FOR PREPARING (S)-4-AMINO-HEPTA-5,6-DIENOIC ACID AND INTERMEDIATES THEREOF | MERRELL PHARMA INC (US) | 1998-01-07 | — | — | EP | claimed |