Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 1/20 | 0.62 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | RHEB | Q15382 | 1/20 | 0.38 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.35 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SCN1A | P35498 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8537111 | 0.92 | MAT2A (0.55) | MAT2ADHODHACP1FNTAPGGT1B | |
| SCHEMBL8536444 | 0.90 | MAT2A (0.64) | MAT2AACP1CYP19A1KIF11KCNH2 | |
| SCHEMBL8530848 | 0.89 | MAT2A (0.77) | MAT2AACP1KIF11DGAT1TRPA1 | |
| SCHEMBL8536602 | 0.88 | MAT2A (0.62) | MAT2AACP1KIF11KCNH2DGAT1 | |
| SCHEMBL8537912 | 0.87 | MAT2A (0.59) | MAT2ADHODHACP1KIF11KCNH2 | |
| SCHEMBL8535958 | 0.86 | MAT2A (0.59) | MAT2AACP1KIF11KCNH2DGAT1 | |
| SCHEMBL8537070 | 0.86 | MAT2A (0.57) | MAT2ADHODHRHEBCYP19A1KIF11 | |
| SCHEMBL8535564 | 0.83 | MAT2A (0.66) | MAT2ADHODHACP1TP53SMN1; SMN2 | |
| SCHEMBL8535303 | 0.83 | MAT2A (0.55) | MAT2ARHEBCYP19A1KIF11TP53 | |
| SCHEMBL8533063 | 0.82 | MAT2A (0.55) | MAT2AACP1KIF11DGAT1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | claimed |
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |