SCHEMBL8535564

SCHEMBL8535564

COc1ccc2[nH]c(-c3ccc(-c4ccc(OC(F)(F)F)cc4)nc3)c(C)c(=O)c2c1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAT2A P31153 1/20 0.66
ALOX5 P09917 1/20 0.44
ABCG2 Q9UNQ0 1/20 0.43
STING1 Q86WV6 1/20 0.42
KDM4E B2RXH2 5/20 0.41
CRHBP P24387 1/20 0.41
CRHR2 Q13324 1/20 0.41
DHODH Q02127 2/20 0.41
TRPV1 Q8NER1 1/20 0.40
ALDH1A1 P00352 5/20 0.39
HPGD P15428 5/20 0.39
NPC1 O15118 3/20 0.39
RAB9A P51151 3/20 0.39
SMN1; SMN2 Q16637 3/20 0.39
LMNA P02545 1/20 0.39
MAPT P10636 2/20 0.39
MTNR1A P48039 1/20 0.39
MTNR1B P49286 1/20 0.39
PIK3CA P42336 1/20 0.39
ESR1 P03372 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8530848 0.92 MAT2A (0.77) MAT2AALOX5KDM4EALDH1A1HPGD
SCHEMBL8537111 0.89 MAT2A (0.55) MAT2AKDM4ECRHBPCRHR2DHODH
SCHEMBL8533063 0.89 MAT2A (0.55) MAT2AALOX5KDM4ECRHBPCRHR2
SCHEMBL8537912 0.88 MAT2A (0.59) MAT2AKDM4ECRHBPCRHR2DHODH
SCHEMBL8535958 0.87 MAT2A (0.59) MAT2AKDM4ECRHBPCRHR2CTSV
SCHEMBL8536444 0.85 MAT2A (0.64) MAT2AKDM4EALDH1A1MAPTKMT2A
SCHEMBL8533188 0.83 MAT2A (0.62) MAT2ADHODHSMN1; SMN2LMNATP53
SCHEMBL8536602 0.83 MAT2A (0.62) MAT2AKDM4ETRPV1ALDH1A1HPGD
SCHEMBL20983234 0.82 MAT2A (0.58) MAT2AALOX5ABCG2STING1KDM4E
SCHEMBL8537269 0.81 MAT2A (0.50) MAT2AABCG2KDM4EALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012069856-A1 ANTIMALARIAL COMPOUNDS LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) 2012-05-31 WO claimed
WO-2012069856-A1 ANTIMALARIAL COMPOUNDS LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) 2012-05-31 WO disclosed
WO-2012069856-A1 ANTIMALARIAL COMPOUNDS LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) 2012-05-31 WO disclosed