SCHEMBL853320

SCHEMBL853320

CC(O)Cc1ccccc1I

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 1/20 0.43
IDO1 P14902 2/20 0.42
GABRA1 P14867 1/20 0.39
GABRB2 P47870 1/20 0.39
CYP1A2 P05177 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
LMNA P02545 1/20 0.36
EYA3 Q99504 1/20 0.36
TRPA1 O75762 2/20 0.34
SIGMAR1 Q99720 1/20 0.33
KDM4E B2RXH2 1/20 0.33
HTR2A P28223 1/20 0.33
HTR2C P28335 1/20 0.33
HTR7 P34969 1/20 0.33
HTR6 P50406 1/20 0.33
ALDH1A1 P00352 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19415512 1.00 TAAR1 (0.43) TAAR1IDO1GABRA1GABRB2CYP1A2
SCHEMBL5988255 0.84 GABRA1 (0.46) TAAR1GABRA1GABRB2LMNATRPA1
SCHEMBL6683911 0.82 GABRA1 (0.52) TAAR1IDO1GABRA1GABRB2CYP1A2
SCHEMBL28059842 0.80 TAAR1 (0.45) TAAR1IDO1GABRA1GABRB2CYP1A2
SCHEMBL3243108 0.79 TAAR1 (0.50) TAAR1IDO1CYP1A2CYP2D6CYP2C9
SCHEMBL4726810 0.79 TAAR1 (0.41) TAAR1IDO1GABRA1GABRB2CYP1A2
SCHEMBL1006209 0.78 SLC6A2 (0.50) TAAR1IDO1CYP1A2CYP2D6LMNA
SCHEMBL24272357 0.78 IDO1 (0.42) TAAR1IDO1GABRA1GABRB2CYP1A2
SCHEMBL1129263 0.76 CYP2D6 (0.41) GABRA1GABRB2CYP2D6LMNATRPA1
SCHEMBL6464989 0.76 GABRA1 (0.40) GABRA1GABRB2LMNATRPA1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008013949-A2 MOLECULAR DESIGN OF THERMOSTABLE ALCOHOL DEHYDROGENASE FOR SYNTHESIS FOR CHIRAL AROMATIC ALCOHOLS MICHIGAN STATE UNIVERSITY (US) 2008-01-31 WO claimed
EP-2432783-A1 MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF Abbott Laboratories (US) 2012-03-28 EP disclosed
WO-2010135560-A1 MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF ABBOTT LABORATORIES (US) 2010-11-25 WO disclosed
EP-2010666-A1 PROCESS FOR DYNAMIC KINETIC RESOLUTION (DKR) OF RACEMIC COMPOUNDS IN (HYDRO) FLUOROCARBON SOLVENTS Ineos Fluor Holdings Limited (GB) 2009-01-07 EP disclosed
WO-2008013949-A2 MOLECULAR DESIGN OF THERMOSTABLE ALCOHOL DEHYDROGENASE FOR SYNTHESIS FOR CHIRAL AROMATIC ALCOHOLS MICHIGAN STATE UNIVERSITY (US) 2008-01-31 WO disclosed
WO-2007129018-A1 PROCESS FOR DYNAMIC KINETIC RESOLUTION (DKR) OF RACEMIC COMPOUNDS IN (HYDRO) FLUOROCARBON SOLVENTS INEOS FLUOR HOLDINGS LIMITED (GB) 2007-11-15 WO disclosed
US-20070184449-A1 Method for the identification of a metabolic pathway family by means of positive selection LIBRAGEN (FR) 2007-08-09 US disclosed