Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SLC29A1 | Q99808 | 5/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.36 |
| ▸ | HINT1 | P49773 | 1/20 | 0.36 |
| ▸ | NT5E | P21589 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
| ▸ | PGK2 | P07205 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8528880 | 0.96 | CYP2C19 (0.36) | CYP2C19SLC29A1ADORA1ADORA3ADORA2A | |
| SCHEMBL8534584 | 0.90 | HINT1 (0.45) | CYP2C19SLC29A1ADORA1ADORA3ADORA2A | |
| SCHEMBL8529064 | 0.88 | CYP2C19 (0.38) | CYP2C19SLC29A1ADORA1ADORA3ADORA2A | |
| SCHEMBL8533343 | 0.76 | HINT1 (0.40) | CYP2C19SLC29A1ADORA1ADORA3ADORA2A | |
| SCHEMBL8529066 | 0.73 | CYP2C19 (0.48) | CYP2C19SLC29A1ADORA1ADORA3ADORA2A | |
| SCHEMBL22408323 | 0.73 | HINT1 (0.51) | HINT1NT5E | |
| SCHEMBL22408273 | 0.73 | HINT1 (0.51) | HINT1NT5E | |
| SCHEMBL25819528 | 0.73 | ADORA1 (0.54) | SLC29A1ADORA1ADORA3ADORA2AADORA2B | |
| SCHEMBL25818697 | 0.73 | ADORA1 (0.54) | SLC29A1ADORA1ADORA3ADORA2AADORA2B | |
| SCHEMBL8533340 | 0.73 | HSP90AA1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821236-A | Tumor treatment with arabinofuranosyl purine derivatives | GLAXO WELLCOME INC. (US) | 1998-10-13 | — | — | US | disclosed |
| US-5747472-A | ANTICARCINOGENIC AGENTS AND ANTITUMOR AGENTS | GLAXO WELLCOME INC. (US) | 1998-05-05 | — | — | US | disclosed |
| US-5492897-A | ANTITUMOR AGENTS, AUTOIMMUNE DISEASES | BURROUGHS WELLCOME CO. (141) (US) | 1996-02-20 | — | — | US | disclosed |
| US-5424295-A | Useful in treatment of varicella-zoster virus infections | BURROUGHS WELLCOME CO. (US) | 1995-06-13 | — | — | US | disclosed |
| WO-1992001456-A1 | HETEROCYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-02-06 | — | — | WO | disclosed |