SCHEMBL8534584

SCHEMBL8534584

COc1nc(N)nc2c1ncn2[C@@H]1O[C@H](COC(C)(C)C)[C@@H](O)[C@@H]1O[SiH](C)C

nearest known ligand 0.45

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HINT1 P49773 2/20 0.45
ADORA3 P0DMS8 3/20 0.43
ADORA1 P30542 3/20 0.43
CYP2C19 P33261 1/20 0.42
NT5E P21589 8/20 0.42
ADORA2A P29274 1/20 0.42
ADORA2B P29275 1/20 0.42
SLC29A1 Q99808 1/20 0.41
RNASEL Q05823 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8528880 0.90 CYP2C19 (0.36) HINT1ADORA3ADORA1CYP2C19NT5E
SCHEMBL8533355 0.90 CYP2C19 (0.36) HINT1ADORA3ADORA1CYP2C19NT5E
SCHEMBL8528882 0.80 HINT1 (0.45) HINT1ADORA3ADORA1CYP2C19NT5E
SCHEMBL8529064 0.79 CYP2C19 (0.38) HINT1ADORA3ADORA1CYP2C19NT5E
SCHEMBL8532634 0.79 ALDH1A1 (0.57) HINT1ADORA3ADORA1CYP2C19NT5E
SCHEMBL15643631 0.78 ADORA3 (0.67) HINT1ADORA3ADORA1CYP2C19NT5E
SCHEMBL16141624 0.78 ADORA3 (0.67) HINT1ADORA3ADORA1CYP2C19NT5E
SCHEMBL8532515 0.78 CYP2C19 (0.52) ADORA3ADORA1CYP2C19ADORA2AADORA2B
SCHEMBL8534590 0.77 HINT1 (0.54) HINT1ADORA3ADORA1CYP2C19NT5E
SCHEMBL8530540 0.76 CYP2C19 (0.54) ADORA3ADORA1CYP2C19ADORA2AADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5821236-A Tumor treatment with arabinofuranosyl purine derivatives GLAXO WELLCOME INC. (US) 1998-10-13 US disclosed
US-5747472-A ANTICARCINOGENIC AGENTS AND ANTITUMOR AGENTS GLAXO WELLCOME INC. (US) 1998-05-05 US disclosed
EP-0539479-B1 HETEROCYCLIC COMPOUNDS WELLCOME FOUND (GB) 1997-04-16 EP disclosed
US-5492897-A ANTITUMOR AGENTS, AUTOIMMUNE DISEASES BURROUGHS WELLCOME CO. (141) (US) 1996-02-20 US disclosed
WO-1992001456-A1 HETEROCYCLIC COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1992-02-06 WO disclosed