Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.34 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1587391 | 0.79 | ALDH1A1 (0.44) | P2RX7TSHRKDM4ENCOA1NCOA3 | |
| SCHEMBL31694898 | 0.79 | ALDH1A1 (0.44) | P2RX7TSHRKDM4ENCOA1NCOA3 | |
| SCHEMBL15130399 | 0.79 | ALDH1A1 (0.44) | P2RX7TSHRKDM4ENCOA1NCOA3 | |
| SCHEMBL3733166 | 0.77 | TSHR (0.52) | TSHRLMNASMN1; SMN2NPSR1 | |
| SCHEMBL26415058 | 0.74 | P2RX7 (0.37) | P2RX7TSHRSRD5A2 | |
| SCHEMBL23201305 | 0.73 | FFAR3 (0.34) | P2RX7TSHRKDM4ENCOA1NCOA3 | |
| SCHEMBL16190004 | 0.70 | P2RX7 (0.37) | P2RX7TSHR | |
| SCHEMBL11105046 | 0.68 | KMT2A (0.38) | TSHRKDM4ESMN1; SMN2SRD5A2 | |
| SCHEMBL23878341 | 0.67 | SMN1; SMN2 (0.38) | TSHRKDM4ELMNASMN1; SMN2 | |
| SCHEMBL14665104 | 0.67 | TSHR (0.52) | TSHRLMNASMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049478-B1 | SUBSTITUTED N-PHENYLMETHYL -5-OXO-PROLINE-2-AMIDES AS P2X7-RECEPTOR ANTAGONISTS AND THEIR METHODS OF USE | GLAXO GROUP LTD (GB) | 2012-05-30 | — | — | EP | disclosed |