SCHEMBL8534375

SCHEMBL8534375

Oc1ccc(SCc2cc(O)c(O)c(O)c2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MIF P14174 1/20 0.47
CA2 P00918 1/20 0.44
NR1H2 P55055 1/20 0.39
IGF1R P08069 1/20 0.37
ALOX15 P16050 1/20 0.37
TYR P14679 1/20 0.37
DAO P14920 3/20 0.36
ALDH1A1 P00352 2/20 0.35
MEN1 O00255 1/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
KMT2A Q03164 1/20 0.35
RET P07949 1/20 0.35
ESR1 P03372 2/20 0.34
ESR2 Q92731 2/20 0.34
KDM4E B2RXH2 1/20 0.34
HTR1A P08908 1/20 0.34
ADRA2A P08913 1/20 0.34
SLC6A2 P23975 1/20 0.34
CYP2C19 P33261 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8529682 0.85 AKR1B1 (0.46) MIFDAOMEN1KMT2ATAAR1
SCHEMBL4542980 0.83 LTA4H (0.50) MIFCA2NR1H2ALOX15TYR
SCHEMBL8533257 0.82 MIF (0.54) MIFCA2IGF1RALOX15DAO
SCHEMBL3241580 0.81 MEN1 (0.50) MIFCA2NR1H2ALDH1A1MEN1
SCHEMBL7782032 0.78 MEN1 (0.46) MIFCA2NR1H2DAOALDH1A1
SCHEMBL8530817 0.77 EGFR (0.46) ALDH1A1KDM4E
SCHEMBL338116 0.75 MAOA (0.58) DAOMEN1NPC1KMT2ASLC6A2
SCHEMBL30820091 0.74 ESR1 (0.46) MIFCA2NR1H2DAOALDH1A1
SCHEMBL12521588 0.73 MIF (0.41) MIFCA2NR1H2ALDH1A1MEN1
SCHEMBL13047673 0.72 MEN1 (0.53) ALOX15DAOALDH1A1MEN1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5840991-A 3,4,5-TRIHYDROXYBENZYL-4-HYDROXYPHENYL THIOETHER DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) 1998-11-24 US claimed
US-5840991-A 3,4,5-TRIHYDROXYBENZYL-4-HYDROXYPHENYL THIOETHER DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) 1998-11-24 US disclosed