Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | REN | P00797 | 2/20 | 0.43 |
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275750 | 0.91 | CA2 (0.43) | RENCTSD | |
| Hydrochloric Acid SCHEMBL8537778 | 0.86 | CA2 (0.40) | RENCTSD | |
| SCHEMBL7336891 | 0.82 | KLK5 (0.52) | KLK5KMT2ARENBACE1CTSD | |
| Hydrochloric Acid SCHEMBL7269731 | 0.79 | BACE1 (0.42) | BACE1CTSD | |
| SCHEMBL7270385 | 0.78 | KLK5 (0.52) | KLK5RENBACE1CTSDPSEN1 | |
| SCHEMBL8531207 | 0.78 | KLK5 (0.61) | KLK5RENBACE1CTSDPSEN1 | |
| SCHEMBL8532173 | 0.78 | KLK5 (0.61) | KLK5RENBACE1CTSDPSEN1 | |
| SCHEMBL6447745 | 0.76 | CTSD (0.66) | KLK5BACE1CTSDPSEN1PSEN2 | |
| SCHEMBL9848360 | 0.75 | KLK5 (0.63) | KLK5KMT2APSEN1PSEN2APH1B | |
| SCHEMBL7270592 | 0.75 | KLK5 (0.63) | KLK5KMT2APSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839798-A2 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1998-05-06 | — | — | EP | disclosed |
| US-5545750-A | TREATING HUMAN IMMUNODEFICIENCY VIRUS | ABBOTT LABORATORIES (US) | 1996-08-13 | — | — | US | disclosed |
| US-5142056-A | Human immunodeficiency virus protease inhibitor | ABBOTT LABORATORIES (US) | 1992-08-25 | — | — | US | disclosed |