Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CTSD | P07339 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CTSE | P14091 | 1/20 | 0.40 |
| ▸ | PGC | P20142 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8537778 | 0.93 | CA2 (0.40) | CA2CTSDHSD17B10CTSEPGC | |
| SCHEMBL8534885 | 0.91 | KLK5 (0.48) | CTSDREN | |
| Hydrochloric Acid SCHEMBL7269731 | 0.86 | BACE1 (0.42) | CA2CTSDCTSEPGCCHRM1 | |
| SCHEMBL7277859 | 0.78 | IL1RN (0.42) | CA2HSD17B10CTSBCTSL | |
| SCHEMBL7277868 | 0.78 | IL1RN (0.42) | CA2HSD17B10CTSBCTSL | |
| SCHEMBL7338355 | 0.78 | CA2 (0.52) | CA2CTSDHSD17B10CTSBCHRM1 | |
| SCHEMBL7268524 | 0.74 | GAA (0.54) | CA2GAACTSL | |
| SCHEMBL7280132 | 0.73 | CTSD (0.61) | CTSDCTSBCTSLCTSSREN | |
| SCHEMBL7268606 | 0.72 | MMP12 (0.39) | CA2 | |
| SCHEMBL7268612 | 0.72 | MMP12 (0.39) | CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839798-A2 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1998-05-06 | — | — | EP | disclosed |
| US-5670675-A | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1997-09-23 | — | — | US | disclosed |
| US-5545750-A | TREATING HUMAN IMMUNODEFICIENCY VIRUS | ABBOTT LABORATORIES (US) | 1996-08-13 | — | — | US | disclosed |
| US-5142056-A | Human immunodeficiency virus protease inhibitor | ABBOTT LABORATORIES (US) | 1992-08-25 | — | — | US | disclosed |
| EP-0402646-A1 | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1990-12-19 | — | — | EP | disclosed |