Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.54 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.36 |
| ▸ | KRAS | P01116 | 1/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30152672 | 0.79 | PDGFRB (0.66) | PDGFRBPDGFRAIRAK1IRAK4PDE10A | |
| SCHEMBL1177940 | 0.72 | PSMD14 (0.41) | — | |
| SCHEMBL1177937 | 0.72 | PSMD14 (0.41) | — | |
| SCHEMBL4299023 | 0.72 | PDGFRB (1.00) | PDGFRBPDGFRAPDE10A | |
| SCHEMBL8532772 | 0.71 | HTR2C (0.54) | SLC6A2SLC6A3 | |
| SCHEMBL7356168 | 0.71 | HTR1A (0.46) | SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL29357672 | 0.70 | PDGFRB (0.96) | PDGFRBPDGFRAPDE10A | |
| SCHEMBL1178222 | 0.70 | SLC6A2 (0.54) | PDE10ASLC6A2SLC6A3PDE3BPDE3A | |
| SCHEMBL1178224 | 0.70 | SLC6A2 (0.54) | PDE10ASLC6A2SLC6A3PDE3BPDE3A | |
| SCHEMBL8536319 | 0.70 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819126-A1 | BIPHENYLAMIDE DERIVATIVES AS 5HT 1D? ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-01-21 | — | — | EP | disclosed |
| WO-1996031508-A1 | BIPHENYLAMIDE DERIVATIVES AS 5HT1D ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-10-10 | — | — | WO | disclosed |