Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 13/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 13/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 13/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.46 |
| ▸ | DRD1 | P21728 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1177937 | 0.78 | PSMD14 (0.41) | — | |
| SCHEMBL1177940 | 0.78 | PSMD14 (0.41) | — | |
| SCHEMBL8534898 | 0.71 | PDGFRB (0.54) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8207826 | 0.70 | HTR2C (0.50) | SLC6A2SLC6A4SLC6A3DRD1DRD2 | |
| SCHEMBL8532772 | 0.70 | HTR2C (0.54) | SLC6A2SLC6A3DRD2DRD4DRD3 | |
| Fumaric Acid SCHEMBL1177636 | 0.69 | KDM4E (0.45) | — | |
| SCHEMBL12093542 | 0.68 | HTR1A (0.57) | HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL17001658 | 0.68 | SSTR4 (0.51) | HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6489917 | 0.67 | OPRM1 (0.59) | — | |
| SCHEMBL6489913 | 0.67 | OPRM1 (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4921860-A | Quinuclidyl- and tropanyl-pyridyl ethers as 5-HT3 receptor antagonists | JOHN WYETH AND BROTHER, LIMITED (GB) | 1990-05-01 | — | — | US | disclosed |