(3R)-Dunnione

(3R)-Dunnione

SCHEMBL8535192

CC1OC2=C(C(=O)C(=O)c3ccccc32)C1(C)C.COC(=O)Nc1nc2ccccc2[nH]1.COC(=O)Nc1nc2ccccc2[nH]1

nearest known ligand 0.44

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NQO1 P15559 3/20 0.44
POR P16435 3/20 0.44
LMNA P02545 6/20 0.43
CYP1A2 P05177 2/20 0.42
ALDH1A1 P00352 2/20 0.42
HTT P42858 2/20 0.42
ABCC4 O15439 1/20 0.42
USP2 O75604 1/20 0.42
ABL1 P00519 1/20 0.42
CYP2C9 P11712 1/20 0.42
KDR P35968 1/20 0.42
HIF1A Q16665 1/20 0.42
SMN1; SMN2 Q16637 3/20 0.42
HPGD P15428 2/20 0.42
POLB P06746 1/20 0.42
BLM P54132 1/20 0.42
RAF1 P04049 5/20 0.42
BRAF P15056 5/20 0.42
MEN1 O00255 5/20 0.42
KMT2A Q03164 5/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Carbendazim SCHEMBL8427009 0.76 LMNA (0.71) LMNACYP1A2ALDH1A1HTTABCC4
Carbendazim SCHEMBL29357746 0.76 LMNA (0.71) LMNACYP1A2ALDH1A1HTTABCC4
Carbendazim SCHEMBL21051 0.76 LMNA (0.71) LMNACYP1A2ALDH1A1HTTABCC4
Carbendazim SCHEMBL5449176 0.75 LMNA (0.69) LMNACYP1A2ALDH1A1HTTABCC4
Carbendazim SCHEMBL11360169 0.75 LMNA (0.69) LMNACYP1A2ALDH1A1HTTABCC4
Carbendazim SCHEMBL8716640 0.75 LMNA (0.69) LMNACYP1A2ALDH1A1HTTABCC4
Carbendazim SCHEMBL74664 0.75 LMNA (0.69) LMNACYP1A2ALDH1A1HTTABCC4
(3R)-Dunnione SCHEMBL103115 0.74 NQO1 (0.63) NQO1PORLMNACYP1A2ALDH1A1
(3R)-Dunnione SCHEMBL29468606 0.74 NQO1 (0.63) NQO1PORLMNACYP1A2ALDH1A1
(3R)-Dunnione SCHEMBL8535310 0.74 NQO1 (0.47) NQO1PORLMNACYP1A2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0861028-A1 FUNGICIDAL COMPOUNDS (B) BTG INTERNATIONAL LIMITED (GB) 1998-09-02 EP disclosed
WO-1997016970-A1 FUNGICIDAL COMPOUNDS (B) BRITISH TECHNOLOGY GROUP LIMITED (GB) 1997-05-15 WO disclosed