Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 5/20 | 0.63 |
| ▸ | POR | P16435 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 3/20 | 0.42 |
| ▸ | RECQL | P46063 | 3/20 | 0.42 |
| ▸ | BLM | P54132 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (3R)-Dunnione SCHEMBL103115 | 1.00 | NQO1 (0.63) | NQO1PORMEN1KMT2AKDM4E | |
| (3R)-Dunnione SCHEMBL6052903 | 0.93 | NQO1 (0.56) | NQO1PORMEN1KMT2AKDM4E | |
| Alpha-Dunnione SCHEMBL940069 | 0.88 | NQO1 (0.56) | NQO1PORMEN1KMT2AKDM4E | |
| SCHEMBL8260282 | 0.86 | NQO1 (0.52) | NQO1PORMEN1KMT2AKDM4E | |
| (3R)-Dunnione SCHEMBL8535310 | 0.83 | NQO1 (0.47) | NQO1PORMEN1KMT2AKDM4E | |
| SCHEMBL6052899 | 0.80 | NQO1 (0.67) | NQO1PORKDM4EMAPTALDH1A1 | |
| SCHEMBL6052838 | 0.79 | NQO1 (0.57) | NQO1PORMEN1KMT2AKDM4E | |
| SCHEMBL14439377 | 0.78 | NQO1 (1.00) | NQO1PORALDH1A1CYP3A4IDO1 | |
| SCHEMBL3331249 | 0.77 | NQO1 (0.50) | NQO1PORMEN1KMT2AKDM4E | |
| SCHEMBL3329489 | 0.77 | NQO1 (0.50) | NQO1PORMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12370170-B2 | Composition comprising naphthoquinone-based compound as active ingredient, for preventing or ameliorating fatigue, cachexia, pain, cognitive decline and hematopoietic stem cell reduction which are side effects related to anticancer drug treatment | NADIANBIO LTD. (KR) | 2025-07-29 | — | — | US | disclosed |
| EP-3449920-B1 | COMPOSITION COMPRISING DUNNIONE OR BETA-LAPACHONE AS ACTIVE INGREDIENT, FOR PREVENTING OR AMELIORATING FATIGUE, PAIN, COGNITIVE DECLINE AND HEMATOPOIETIC STEM CELL REDUCTION WHICH ARE SIDE EFFECTS RELATED TO ANTICANCER DRUG TREATMENT | NADIANBIO LTD (KR) | 2025-05-28 | — | — | EP | disclosed |
| EP-3741366-B1 | COMPOSITION COMPRISING DUNNIONE AS EFFECTIVE INGREDIENT FOR PREVENTION OR ALLEVIATION OF HAIR LOSS | NADIANBIO LTD (KR) | 2024-12-11 | — | — | EP | disclosed |
| US-20230372286-A1 | COMPOSITION COMPRISING NAPHTHOQUINONE-BASED COMPOUND AS ACTIVE INGREDIENT, FOR PREVENTING OR AMELIORATING FATIGUE, CACHEXIA, PAIN, COGNITIVE DECLINE AND HEMATOPOIETIC STEM CELL REDUCTION WHICH ARE SIDE EFFECTS RELATED TO ANTICANCER DRUG TREATMENT | NADIANBIO LTD. (KR) | 2023-11-23 | — | — | US | disclosed |
| CN-111323464-B | System for quantitative detection of NQO1 enzyme activity and drug screening, and electroluminescence sensing method and application thereof | 东南大学 | 2023-04-21 | — | — | CN | disclosed |
| CN-115803060-A | Pharmaceutical composition for preventing or treating cancer comprising naphthoquinone-based compound and immune checkpoint inhibitor as active ingredients | (株) 娜迪安生物公司 | 2023-03-14 | — | — | CN | disclosed |
| US-11278514-B2 | Composition compromising dunnione as effective ingredient for prevention or alleviation of hair loss | NADIANBIO LTD. (KR) | 2022-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12370170-B2 | Composition comprising naphthoquinone-based compound as active ingredient, for preventing or ameliorating fatigue, cachexia, pain, cognitive decline and hematopoietic stem cell reduction which are side effects related to anticancer drug treatment | ACHE, NES, GSTO1 | NQO1 11/4885POR 2987/4885MEN1 2130/4885 |
| US-11278514-B2 | Composition compromising dunnione as effective ingredient for prevention or alleviation of hair loss | SPIN3, SHARPIN, DVL3 | NQO1 189/4885POR 765/4885MEN1 3364/4885 |
| US-20230372286-A1 | COMPOSITION COMPRISING NAPHTHOQUINONE-BASED COMPOUND AS ACTIVE INGREDIENT, FOR PREVENTING OR AMELIORATING FATIGUE, CACHEXIA, PAIN, COGNITIVE DECLINE AND HEMATOPOIETIC STEM CELL REDUCTION WHICH ARE SIDE EFFECTS RELATED TO ANTICANCER DRUG TREATMENT | ACHE, NES, GSTO1 | NQO1 11/4885POR 2987/4885MEN1 2130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.