Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | QDPR | P09417 | 1/20 | 0.45 |
| ▸ | RBP4 | P02753 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4771915 | 0.88 | MEN1 (0.52) | PDE4BMEN1KMT2AQDPRALDH1A1 | |
| SCHEMBL5515302 | 0.88 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL6815771 | 0.84 | MEN1 (0.45) | PDE4BMEN1KMT2AQDPRRBP4 | |
| SCHEMBL8534478 | 0.81 | MEN1 (0.71) | MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7029357 | 0.80 | QDPR (0.52) | MEN1KMT2AQDPRALDH1A1LMNA | |
| SCHEMBL4206124 | 0.80 | PDE4B (0.48) | PDE4BMEN1KMT2A | |
| SCHEMBL7938441 | 0.80 | KDM4E (0.46) | ALDH1A1LMNAMAPT | |
| SCHEMBL6924205 | 0.78 | ABCB1 (0.43) | ALDH1A1LMNAMAPT | |
| SCHEMBL31257859 | 0.78 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL282618 | 0.78 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4DMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819126-A1 | BIPHENYLAMIDE DERIVATIVES AS 5HT 1D? ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-01-21 | — | — | EP | disclosed |
| WO-1996031508-A1 | BIPHENYLAMIDE DERIVATIVES AS 5HT1D ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-10-10 | — | — | WO | disclosed |