Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8535555 | 0.78 | ATM (0.50) | KLK5KMT2AATMMEN1APP | |
| SCHEMBL9011708 | 0.77 | CTSB (0.44) | KMT2AMEN1CTSSCTSLCTSB | |
| SCHEMBL15095217 | 0.77 | ATM (0.46) | KLK5KMT2AATMMEN1APP | |
| SCHEMBL9011901 | 0.75 | CTSB (0.44) | KMT2AATMMEN1CTSSCTSL | |
| SCHEMBL9012148 | 0.75 | CTSB (0.44) | KMT2AATMMEN1CTSSCTSL | |
| SCHEMBL6446223 | 0.71 | ATM (0.50) | KLK5KMT2AATMMEN1APP | |
| SCHEMBL1414624 | 0.67 | CTSK (0.52) | KLK5KMT2AATMMEN1APP | |
| SCHEMBL7269319 | 0.67 | KLK5 (0.59) | KLK5ATMAPPCTSSPSEN1 | |
| SCHEMBL20516430 | 0.67 | ATM (0.52) | KLK5KMT2AATMMEN1APP | |
| SCHEMBL20516427 | 0.67 | ATM (0.52) | KLK5KMT2AATMMEN1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712417-A | Inhibitors of retroviral proteases | ABBOTT LABORATORIES (US) | 1998-01-27 | — | — | US | disclosed |
| EP-0428849-A2 | Retroviral protease inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-05-29 | — | — | EP | disclosed |