SCHEMBL8535573

SCHEMBL8535573

Clc1ccc([C@H]2OC2c2ccccc2)c(Cl)c1

nearest known ligand 0.43

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.43
HTT P42858 2/20 0.43
MAPT P10636 1/20 0.43
THRB P10828 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
DPP4 P27487 2/20 0.41
HTR2A P28223 1/20 0.40
HTR2C P28335 1/20 0.40
HTR2B P41595 1/20 0.40
KDM1A O60341 1/20 0.38
MAOA P21397 1/20 0.37
MAOB P27338 1/20 0.37
TRPM4 Q8TD43 1/20 0.37
TRPM5 Q9NZQ8 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7459225 1.00 ALDH1A1 (0.43) ALDH1A1HTTMAPTTHRBNPSR1
SCHEMBL11690285 0.88 HTR2A (0.47) ALDH1A1HTTMAPTTHRBNPSR1
SCHEMBL10689288 0.80 TBXAS1 (0.47) ALDH1A1HTTMAPTTRPM5
SCHEMBL93210 0.80 SLC6A3 (0.41) ALDH1A1DPP4HTR2AHTR2CHTR2B
SCHEMBL9592593 0.78 TBXAS1 (0.50) ALDH1A1HTTMAPTDPP4TRPM5
SCHEMBL4388070 0.78 TSHR (0.48) ALDH1A1HTTMAPTNPSR1KDM1A
SCHEMBL4388071 0.78 TSHR (0.48) ALDH1A1HTTMAPTNPSR1KDM1A
SCHEMBL20537532 0.77 DPP4 (0.39) ALDH1A1HTTMAPTTHRBNPSR1
SCHEMBL20537615 0.77 DPP4 (0.39) ALDH1A1HTTMAPTTHRBNPSR1
SCHEMBL20537467 0.77 DPP4 (0.39) ALDH1A1HTTMAPTTHRBNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0839035-A2 ANTIFUNGAL AGENT, COMPOUND THEREFOR, PROCESS FOR PRODUCING THE SAME Nihon Nohyaku Co., Ltd. (JP) 1998-05-06 EP disclosed
WO-1997002821-A2 ANTIFUNGAL AGENT, COMPOUND THEREFOR, PROCESS FOR PRODUCING THE SAME NIHON NOHYAKU CO., LTD. (JP) 1997-01-30 WO disclosed