Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Prochloraz. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.80 |
| ▸ | TBXAS1 | P24557 | 4/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ADH5 | P11766 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prochloraz SCHEMBL11404537 | 0.93 | AHR (0.83) | AHRADRB2ADRB1ADRB3MEN1 | |
| Prochloraz SCHEMBL9316172 | 0.92 | AHR (0.76) | AHRTBXAS1MRGPRX4ADRB2ADRB1 | |
| Prochloraz SCHEMBL1478635 | 0.92 | AHR (0.96) | AHRADRB2ADRB1ADRB3MEN1 | |
| Prochloraz SCHEMBL29353284 | 0.91 | AHR (0.86) | AHRADRB2ADRB1ADRB3MEN1 | |
| Prochloraz SCHEMBL4745585 | 0.90 | AHR (0.85) | AHRADRB2ADRB1ADRB3MEN1 | |
| Prochloraz SCHEMBL7381517 | 0.90 | AHR (0.85) | AHRADRB2ADRB1ADRB3MEN1 | |
| Prochloraz SCHEMBL9291992 | 0.90 | AHR (0.88) | AHRADRB2ADRB1ADRB3MEN1 | |
| Prochloraz SCHEMBL34675 | 0.90 | AHR (1.00) | AHRADRB2ADRB1ADRB3MEN1 | |
| Prochloraz SCHEMBL22242 | 0.90 | AHR (1.00) | AHRADRB2ADRB1ADRB3MEN1 | |
| Prochloraz SCHEMBL29551185 | 0.89 | AHR (0.86) | AHRADRB2ADRB1ADRB3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0432984-B1 | Carbamoyl derivatives | ZENECA LTD (GB) | 1998-03-04 | — | — | EP | disclosed |