Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PMM2 | O15305 | 1/20 | 0.40 |
| ▸ | MPI | P34949 | 1/20 | 0.40 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.38 |
| ▸ | RARG | P13631 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8533938 | 0.85 | ALDH1A1 (0.53) | MEN1KMT2AALDH1A1HPGDMAPT | |
| SCHEMBL11749787 | 0.84 | SIRT1 (0.61) | MEN1KMT2AALDH1A1HPGDMAPT | |
| SCHEMBL8530163 | 0.83 | ALDH1A1 (0.54) | MEN1KMT2AALDH1A1HPGDMAPT | |
| SCHEMBL16495410 | 0.82 | ERN1 (0.50) | MEN1KMT2AALDH1A1HPGDMAPT | |
| SCHEMBL5833804 | 0.82 | KMT2A (0.50) | MEN1KMT2AALDH1A1HPGDMAPT | |
| SCHEMBL8533542 | 0.81 | SLC6A4 (0.57) | MEN1KMT2AALDH1A1HPGDMAPT | |
| SCHEMBL8534092 | 0.81 | ALDH1A1 (0.69) | MEN1KMT2AALDH1A1HPGDMAPT | |
| SCHEMBL2480090 | 0.77 | HPGD (0.60) | MEN1KMT2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8529733 | 0.77 | MEN1 (0.54) | MEN1KMT2AALDH1A1HPGDMAPT | |
| SCHEMBL1447741 | 0.75 | KDM4E (0.59) | ALDH1A1HPGDMAPTSIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922914-A | REDUCING 2,4-DIHYDRO-6-METHYL-4-PHENYL-2H-BENZOPYRAN-2-ONE WITH A REDUCING AGENT TO FORM 3,4-DIHYDRO-6-METHYL-4-PHENYL-2H-BENZOPYRAN-2-OL CHEMICAL INTERMEDIATE, REDUCTIVELY AMINATING THE HYDROXY COMPOUND | PHARMACIA & UPJOHN COMPANY (US) | 1999-07-13 | — | — | US | claimed |
| EP-0859757-A1 | DERIVATES OF N,N-DIMETHYL-2-(ARYLTHIO)BENZYLAMINE, THEIR SALTS, METHODS OF PREPARATION AND THEIR USE IN PHARMACEUTICAL MEDICAMENTS | Farmak A.S. (CZ) | 1998-08-26 | — | — | EP | disclosed |
| WO-1997017325-A1 | DERIVATES OF N,N-DIMETHYL-2-(ARYLTHIO)BENZYLAMINE, THEIR SALTS, METHODS OF PREPARATION AND THEIR USE IN PHARMACEUTICAL MEDICAMENTS | FARMAK A.S. (CZ) | 1997-05-15 | — | — | WO | disclosed |