Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.61 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.60 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.60 |
| ▸ | ACHE | P22303 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 2/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21360586 | 0.90 | KDM4E (0.51) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| SCHEMBL9344489 | 0.90 | KDM4E (0.68) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| SCHEMBL620074 | 0.89 | POLB (0.66) | KDM4ELMNATSHRALDH1A1MAPK1 | |
| SCHEMBL3000922 | 0.89 | POLB (0.58) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| SCHEMBL18874371 | 0.87 | LMNA (0.49) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| SCHEMBL3399829 | 0.87 | LMNA (0.64) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| SCHEMBL11230329 | 0.86 | KDM4E (0.63) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| SCHEMBL12515200 | 0.86 | KDM4E (0.63) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| SCHEMBL9419699 | 0.84 | MAPK1 (0.65) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| SCHEMBL11619588 | 0.84 | TSHR (0.70) | KDM4EMAPTHIF1ASLC22A6SLC22A8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 147 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025085689-A1 | EXTRACELLULAR SMALL MOLECULE ACTIVATORS TARGETING BESTROPHIN CHANNELS FOR DISEASE TREATMENT | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2025-04-24 | — | — | WO | claimed |
| CN-116874266-B | Detachable acoustic insulation board and manufacturing method thereof | 宝都国际新材料有限公司 | 2023-12-12 | — | — | CN | claimed |
| CN-116874266-A | Detachable acoustic insulation board and manufacturing method thereof | 宝都国际新材料有限公司 | 2023-10-13 | — | — | CN | claimed |
| CN-116496452-A | Low-sensitivity super-early-strength polycarboxylate superplasticizer and preparation method thereof | 厦门路桥翔通建材科技有限公司 | 2023-07-28 | — | — | CN | claimed |
| US-20100190773-A1 | Anti-Cytokine Heterocyclic Compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-07-29 | — | — | US | claimed |
| EP-2188289-A2 | (7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-PIPERAZINES AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATION | Lexicon Pharmaceuticals, Inc. (US) | 2010-05-26 | — | — | EP | claimed |
| WO-2009021169-A2 | (7H-PYRR0L0 [2, 3-D] PYRIMIDIN-4-YL) -PIPERAZINES AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATION | LEXICON PHARMACEUTICALS, INC. (US) | 2009-02-12 | — | — | WO | claimed |
| US-20060276496-A1 | Anti-Cytokine Heterocyclic Compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2006-12-07 | — | — | US | claimed |
| WO-2025085689-A1 | EXTRACELLULAR SMALL MOLECULE ACTIVATORS TARGETING BESTROPHIN CHANNELS FOR DISEASE TREATMENT | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2025-04-24 | — | — | WO | disclosed |
| EP-4306532-A2 | CHEMICAL CLEAVAGE AND DEPROTECTION | Illumina, Inc. (US) | 2024-01-17 | — | — | EP | disclosed |
| CN-116874266-B | Detachable acoustic insulation board and manufacturing method thereof | 宝都国际新材料有限公司 | 2023-12-12 | — | — | CN | disclosed |
| CN-116874266-B | Detachable acoustic insulation board and manufacturing method thereof | 宝都国际新材料有限公司 | 2023-12-12 | — | — | CN | disclosed |
| WO-2023220440-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2023-11-16 | — | — | WO | disclosed |
| EP-3794012-B1 | COMPOSITIONS AND METHODS FOR CHEMICAL CLEAVAGE AND DEPROTECTION OF SURFACE-BOUND OLIGONUCLEOTIDES | ILLUMINA INC (US) | 2023-10-18 | — | — | EP | disclosed |
| US-5405851-A | Administering benzoquinazoline thymidylate synthase inhibitors | BURROUGHS WELLCOME CO. (US) | 1995-04-11 | — | — | US | disclosed |
| US-5298036-A | Polyamide fibers | CIBA-GEIGY CORPORATION (US) | 1994-03-29 | — | — | US | disclosed |
| EP-0535034-A1 | PHARMACEUTICALLY ACTIVE BENZOQUINAZOLINE COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-04-07 | — | — | EP | disclosed |
| WO-1991019700-A1 | PHARMACEUTICALLY ACTIVE BENZOQUINAZOLINE COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-12-26 | — | — | WO | disclosed |
| US-4642322-A | Stabilization of chlorine-containing thermoplastics with nitrogen-containing organic compounds | CIBA-GEIGY CORPORATION (US) | 1987-02-10 | — | — | US | disclosed |
| US-4412992-A | 2-Hydroxy-5-phenylazobenzoic acid derivatives and method of treating ulcerative colitis therewith | BIOREX LABORATORIES LIMITED (GB) | 1983-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276496-A1 | Anti-Cytokine Heterocyclic Compounds | MAPKAPK2, MAP4K2, MAP3K2 | KDM4E 2943/4885MAPT 1938/4885HIF1A 2401/4885 |
| US-20100190773-A1 | Anti-Cytokine Heterocyclic Compounds | MAPKAPK2, MAP4K2, MAP3K2 | KDM4E 2943/4885MAPT 1938/4885HIF1A 2401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.