Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8532689 | 0.88 | GPR84 (0.49) | GPR84RXFP1MAPTALDH1A1RAB9A | |
| SCHEMBL8533040 | 0.86 | GPR84 (0.46) | GPR84MAPTALDH1A1TSHRNPC1 | |
| SCHEMBL8533902 | 0.86 | GPR84 (0.46) | GPR84MAPTALDH1A1TSHRNPC1 | |
| SCHEMBL8532302 | 0.83 | GPR84 (0.45) | GPR84RXFP1MAPTALDH1A1NPC1 | |
| SCHEMBL9373727 | 0.82 | PPARA (0.41) | GPR84RXFP1MAPTNPC1CDK2 | |
| SCHEMBL9489476 | 0.82 | THRA (0.43) | GPR84RXFP1MAPTALDH1A1NPC1 | |
| SCHEMBL3671157 | 0.81 | GPR84 (0.42) | GPR84RXFP1MAPTNPC1KMT2A | |
| SCHEMBL8530246 | 0.81 | GPR84 (0.65) | GPR84RXFP1MAPTCYP3A4ALDH1A1 | |
| SCHEMBL10469189 | 0.80 | GPR84 (0.39) | GPR84MAPTALDH1A1NPC1CDK2 | |
| SCHEMBL8536466 | 0.80 | CA12 (0.47) | TSHRRAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0432984-B1 | Carbamoyl derivatives | ZENECA LTD (GB) | 1998-03-04 | — | — | EP | disclosed |
| US-5334765-A | Intermediate for leukotriene antagonists | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-08-02 | — | — | US | disclosed |
| US-5286740-A | Leukotrine antagonists; antiinflammatory agnets, antiallergens, treating asthma | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-02-15 | — | — | US | disclosed |
| EP-0432984-A2 | Carbamoyl derivatives | ZENECA LIMITED (GB) | 1991-06-19 | — | — | EP | disclosed |