Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 4/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8539012 | 0.88 | MAPT (0.53) | MAPTL3MBTL1TDP1HPGDALDH1A1 | |
| SCHEMBL8902457 | 0.88 | MAPT (0.53) | MAPTL3MBTL1TDP1HPGDALDH1A1 | |
| SCHEMBL8536556 | 0.88 | MAPT (0.53) | MAPTL3MBTL1TDP1HPGDALDH1A1 | |
| SCHEMBL11444316 | 0.88 | MAPT (0.53) | MAPTL3MBTL1TDP1HPGDALDH1A1 | |
| SCHEMBL8535069 | 0.88 | MAPT (0.53) | MAPTL3MBTL1TDP1HPGDALDH1A1 | |
| SCHEMBL11433262 | 0.86 | MAPT (0.54) | MAPTL3MBTL1TDP1HPGDALDH1A1 | |
| SCHEMBL11565117 | 0.81 | MAPT (0.51) | MAPTL3MBTL1TDP1HPGDALDH1A1 | |
| SCHEMBL12978667 | 0.80 | ALDH1A1 (0.54) | MAPTL3MBTL1HPGDALDH1A1CYP2C9 | |
| SCHEMBL14968907 | 0.80 | L3MBTL1 (0.50) | MAPTL3MBTL1TDP1HPGDALDH1A1 | |
| SCHEMBL8903264 | 0.78 | MAPT (0.60) | MAPTL3MBTL1TDP1HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750532-A | TETRAHYDROPYRIMIDINE-2,4-DIONE DERIVATIVES, VIRICIDES, ANTIINFLAMMATORY AGENTS, PAF INHIBITORS | SCHERING CORPORATION (US) | 1998-05-12 | — | — | US | disclosed |
| US-5459144-A | Enterovirus and rhinovirus antiviral, antiinflammatory and antagonist of platelet activating factor | SCHERING CORPORATION (US) | 1995-10-17 | — | — | US | disclosed |
| US-5272167-A | Pharmaceutically active compounds | SCHERING CORPORATION (US) | 1993-12-21 | — | — | US | disclosed |
| WO-1991000858-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS | SCHERING CORPORATION (US) | 1991-01-24 | — | — | WO | disclosed |
| EP-0407217-A1 | Pharmaceutically active compounds | SCHERING CORPORATION (US) | 1991-01-09 | — | — | EP | disclosed |