Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | VDR | P11473 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8536161 | 0.77 | ALDH1A1 (0.43) | ALDH1A1TSHRMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL6928223 | 0.76 | ALDH1A1 (0.45) | ALDH1A1TSHRRAB9AL3MBTL1LMNA | |
| SCHEMBL8532701 | 0.76 | ALDH1A1 (0.42) | ALDH1A1TSHRMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL6922966 | 0.74 | ALDH1A1 (0.43) | ALDH1A1TSHRMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL9593156 | 0.72 | PDE4A (0.43) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8563542 | 0.71 | ALDH1A1 (0.39) | ALDH1A1TSHRMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL20752451 | 0.69 | BRD4 (0.44) | ALDH1A1TSHRRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL6970946 | 0.69 | TSHR (0.40) | ALDH1A1TSHRMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL6030662 | 0.68 | KDM4E (0.52) | ALDH1A1TSHRVDRMAPTRAB9A | |
| SCHEMBL12650380 | 0.67 | ALDH1A1 (0.50) | ALDH1A1TSHRRAB9ASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719140-A | ANALGESICS, PROSTAGLANDIN-E2 ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0696283-B1 | 2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- AND/OR 10-SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | SEARLE & CO (US) | 1997-09-17 | — | — | EP | disclosed |
| US-5395932-A | Analgesics, prostaglandin E2 inhibitors | G. D. SEARLE & CO. (US) | 1995-03-07 | — | — | US | disclosed |
| WO-1994025456-A1 | 2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- AND/OR 10-SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | G.D. SEARLE & CO. (US) | 1994-11-10 | — | — | WO | disclosed |