Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | MYC | P01106 | 1/20 | 0.31 |
| ▸ | TTR | P02766 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8911745 | 0.69 | MAPT (0.36) | LMNAHSP90AA1MAPTHTTSMN1; SMN2 | |
| SCHEMBL8363308 | 0.66 | TDP1 (0.34) | MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL17583241 | 0.65 | KDM4C (0.32) | MAPTHTTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL27848261 | 0.65 | MAPT (0.46) | LMNAHSP90AA1MAPTHTTSMN1; SMN2 | |
| SCHEMBL6651141 | 0.64 | MAPT (0.38) | LMNAHSP90AA1MAPTHTTSMN1; SMN2 | |
| SCHEMBL7966091 | 0.63 | — | — | |
| SCHEMBL9057850 | 0.62 | MYC (0.36) | MYCTTR | |
| SCHEMBL5812357 | 0.61 | MAPT (0.36) | LMNAHSP90AA1MAPTHTTSMN1; SMN2 | |
| SCHEMBL18862390 | 0.61 | ACHE (0.30) | — | |
| SCHEMBL9959991 | 0.59 | IDO1 (0.39) | LMNAHSP90AA1MAPTHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5770598-A | ANTITUMOR AGENTS; REACTING WITH CARBONYL DIIMIDAZOLE AND AMIDOXIMES | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 1998-06-23 | — | — | US | disclosed |