Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.36 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8910413 | 0.89 | FGB (0.41) | MAPTSMN1; SMN2LMNAALDH1A1KDM4E | |
| SCHEMBL1388443 | 0.76 | DHODH (0.38) | MAPTRAB9ASMN1; SMN2NPC1LMNA | |
| SCHEMBL7966221 | 0.74 | TDP1 (0.38) | MAPTRAB9ASMN1; SMN2NPC1LMNA | |
| SCHEMBL9434331 | 0.74 | TDP1 (0.36) | MAPTRAB9ASMN1; SMN2NPC1LMNA | |
| SCHEMBL9434825 | 0.72 | DHODH (0.38) | MAPTRAB9AALDH1A1GPBAR1CYP1A2 | |
| SCHEMBL1388453 | 0.72 | TDP1 (0.35) | MAPTRAB9ASMN1; SMN2NPC1LMNA | |
| SCHEMBL9212581 | 0.72 | DHODH (0.38) | MAPTRAB9ASMN1; SMN2NPC1LMNA | |
| SCHEMBL8363373 | 0.69 | TDP1 (0.38) | MAPTRAB9ASMN1; SMN2NPC1LMNA | |
| SCHEMBL8911173 | 0.65 | TDP1 (0.39) | MAPTRAB9ASMN1; SMN2NPC1LMNA | |
| SCHEMBL26773019 | 0.65 | ALDH1A1 (0.59) | MAPTRAB9ASMN1; SMN2NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5679694-A | LOW TOXICITY AGAINST NORMAL CELL LINES | THE WELLCOME FOUNDATION LTD. (GB) | 1997-10-21 | — | — | US | disclosed |
| CN-1088209-A | Heterogeneous ring compound | WELLCOME FOUND (GB) | 1994-06-22 | — | — | CN | disclosed |
| WO-1994002483-A1 | TETRACYCLIC COMPOUNDS PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOUR AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-02-03 | — | — | WO | disclosed |