Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | GALR2 | O43603 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8543074 | 0.91 | ALDH1A1 (0.38) | ALDH1A1PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL8543433 | 0.88 | TXNRD1 (0.39) | ALDH1A1PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL8538229 | 0.87 | TXNRD1 (0.44) | ALDH1A1PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL8544140 | 0.86 | TXNRD1 (0.46) | ALDH1A1VCAM1THRB | |
| SCHEMBL8538826 | 0.85 | VCAM1 (0.49) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL8538227 | 0.84 | PDGFRB (0.36) | ALDH1A1PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL8542930 | 0.83 | VCAM1 (0.38) | ALDH1A1PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL8544879 | 0.83 | ALDH1A1 (0.37) | ALDH1A1PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL27373139 | 0.82 | ALDH1A1 (0.38) | ALDH1A1PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL8540078 | 0.82 | VCAM1 (0.37) | ALDH1A1PDGFRBFGFR1PDGFRAFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5744641-A | Sulfonyl- or sulfinylbenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-28 | — | — | US | disclosed |