Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9024286 | 0.79 | C3AR1 (0.45) | NAMPTMAPTALDH1A1HTTKDM4E | |
| SCHEMBL4489396 | 0.79 | NAMPT (0.54) | NAMPTMAPTALDH1A1HTTKDM4E | |
| SCHEMBL8541059 | 0.78 | NPC1 (0.51) | MAPTALDH1A1HTTSMN1; SMN2RAB9A | |
| SCHEMBL24636716 | 0.76 | MAPT (0.60) | NAMPTMAPTALDH1A1HTTKDM4E | |
| SCHEMBL11295721 | 0.76 | MAPT (0.51) | NAMPTMAPTALDH1A1HTTKDM4E | |
| SCHEMBL11856687 | 0.75 | GAA (0.53) | NAMPTMAPTALDH1A1HTTKDM4E | |
| SCHEMBL11618745 | 0.72 | NAMPT (0.65) | NAMPTMAPTALDH1A1HTTKDM4E | |
| SCHEMBL6716687 | 0.72 | CRHBP (0.61) | NAMPTMAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL27300824 | 0.71 | MAPT (0.54) | MAPTALDH1A1HTTKDM4ESMN1; SMN2 | |
| SCHEMBL10881254 | 0.71 | SMN1; SMN2 (0.44) | NAMPTMAPTHTTGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715627-B1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LTD (GB) | 1998-09-09 | — | — | EP | disclosed |
| US-5744488-A | 1-CARBOXYALKYL-3-ALKYL OR PHENYL-5-ORGANOSULFONAMIDE OR -AMIDE INDOLES; ATHERSCLEROSIS; ANGINA; PREVENTING ANGIOPLASTY OCCULSION; THROMBOXANE SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-04-28 | — | — | US | disclosed |
| WO-1995006046-A1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LIMITED (GB) | 1995-03-02 | — | — | WO | disclosed |