Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8684915 | 0.90 | TDP1 (0.51) | NPC1RAB9ATDP1HTTMAPT | |
| SCHEMBL8535825 | 0.82 | LTA4H (0.50) | HRH3HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL10959930 | 0.79 | CA12 (0.57) | NPC1MEN1KMT2A | |
| SCHEMBL16902850 | 0.78 | TDP1 (0.73) | NPC1RAB9ATDP1HTTMAPT | |
| SCHEMBL16902871 | 0.78 | TDP1 (0.73) | NPC1RAB9ATDP1HTTMAPT | |
| SCHEMBL16902857 | 0.78 | TDP1 (0.73) | NPC1RAB9ATDP1HTTMAPT | |
| SCHEMBL16902859 | 0.78 | TDP1 (0.73) | NPC1RAB9ATDP1HTTMAPT | |
| SCHEMBL16902870 | 0.78 | TDP1 (0.73) | NPC1RAB9ATDP1HTTMAPT | |
| SCHEMBL16902856 | 0.78 | TDP1 (0.73) | NPC1RAB9ATDP1HTTMAPT | |
| SCHEMBL16902858 | 0.78 | TDP1 (0.73) | NPC1RAB9ATDP1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750532-A | TETRAHYDROPYRIMIDINE-2,4-DIONE DERIVATIVES, VIRICIDES, ANTIINFLAMMATORY AGENTS, PAF INHIBITORS | SCHERING CORPORATION (US) | 1998-05-12 | — | — | US | disclosed |