Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.67 |
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.59 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8539273 | 0.93 | GPBAR1 (0.65) | GPBAR1CYSLTR1FFAR1AKR1B1ALOX5 | |
| SCHEMBL8543705 | 0.91 | CYSLTR1 (0.61) | GPBAR1CYSLTR1FFAR1AKR1B1NR1H4 | |
| SCHEMBL9203135 | 0.90 | CYSLTR1 (0.65) | GPBAR1CYSLTR1 | |
| SCHEMBL8538426 | 0.90 | CYSLTR1 (0.65) | GPBAR1CYSLTR1ALOX5CYSLTR2 | |
| SCHEMBL8540124 | 0.84 | CYSLTR1 (0.60) | GPBAR1CYSLTR1FFAR1AKR1B1ALOX5 | |
| SCHEMBL8617516 | 0.83 | CYSLTR1 (0.64) | GPBAR1CYSLTR1ALOX5CYSLTR2 | |
| SCHEMBL8543517 | 0.82 | GPBAR1 (0.55) | GPBAR1CYSLTR1FFAR1AKR1B1ALOX5 | |
| SCHEMBL8619368 | 0.82 | GPBAR1 (0.57) | GPBAR1CYSLTR1FFAR1AKR1B1ALOX5 | |
| SCHEMBL9199864 | 0.82 | CYSLTR1 (0.60) | GPBAR1CYSLTR1CYSLTR2 | |
| SCHEMBL7718896 | 0.81 | GPBAR1 (0.90) | GPBAR1CYSLTR1FFAR1AKR1B1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539117-B1 | Compounds useful as leukotriene antagonists | LILLY CO ELI (GB) | 1998-03-11 | — | — | EP | disclosed |
| US-5410061-A | Leukotriene antagonist | LILLY INDUSTRIES LIMITED (GB) | 1995-04-25 | — | — | US | disclosed |
| EP-0539117-A1 | Compounds useful as leukotriene antagonists | LILLY INDUSTRIES LIMITED (GB) | 1993-04-28 | — | — | EP | disclosed |