Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 12/20 | 0.65 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.65 |
| ▸ | CYSLTR2 | Q9NS75 | 7/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8617516 | 0.93 | CYSLTR1 (0.64) | CYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL8538241 | 0.91 | CYSLTR1 (0.67) | CYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL8538239 | 0.90 | GPBAR1 (0.67) | CYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL9203135 | 0.85 | CYSLTR1 (0.65) | CYSLTR1GPBAR1 | |
| SCHEMBL8616407 | 0.84 | CYSLTR1 (0.66) | CYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL8539273 | 0.83 | GPBAR1 (0.65) | CYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL7711072 | 0.81 | GPBAR1 (0.80) | CYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL7716691 | 0.81 | CYSLTR1 (0.88) | CYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL8543705 | 0.81 | CYSLTR1 (0.61) | CYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL9199593 | 0.80 | CYSLTR1 (0.56) | CYSLTR1GPBAR1CYSLTR2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539117-B1 | Compounds useful as leukotriene antagonists | LILLY CO ELI (GB) | 1998-03-11 | — | — | EP | disclosed |
| US-5410061-A | Leukotriene antagonist | LILLY INDUSTRIES LIMITED (GB) | 1995-04-25 | — | — | US | disclosed |
| EP-0539117-A1 | Compounds useful as leukotriene antagonists | LILLY INDUSTRIES LIMITED (GB) | 1993-04-28 | — | — | EP | disclosed |