Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 12/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 3/20 | 0.34 |
| ▸ | CES2 | O00748 | 2/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8537164 | 0.99 | THRB (0.41) | THRBFAAHCES2CES1CNR2 | |
| SCHEMBL8539475 | 0.96 | THRB (0.35) | THRBEGLN1CNR1CNR2CCR2 | |
| SCHEMBL8538519 | 0.91 | EGLN1 (0.40) | THRBEGLN1CCR2 | |
| SCHEMBL8537724 | 0.88 | THRB (0.41) | THRBEGLN1FAAHCES2CES1 | |
| SCHEMBL8540996 | 0.87 | DDR1 (0.39) | EGLN1CCR2 | |
| SCHEMBL8539428 | 0.86 | THRB (0.43) | THRBEGLN1FAAHCES2CES1 | |
| SCHEMBL8539830 | 0.84 | THRB (0.37) | THRBEGLN1CNR1CNR2CCR2 | |
| SCHEMBL6936738 | 0.82 | SLC9A1 (0.50) | — | |
| SCHEMBL6937384 | 0.82 | SLC9A1 (0.49) | — | |
| SCHEMBL8537834 | 0.81 | SLC9A1 (0.43) | THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5744641-A | Sulfonyl- or sulfinylbenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-28 | — | — | US | disclosed |