Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 1/20 | 0.52 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | CTSV | O60911 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | KIF11 | P52732 | 2/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8532528 | 0.92 | MAT2A (0.48) | MAT2ACCNT1CCNE1CDK2CDK9 | |
| SCHEMBL8535293 | 0.92 | MAT2A (0.48) | MAT2ACCNT1CCNE1CDK2CDK9 | |
| SCHEMBL8533461 | 0.88 | MAT2A (0.56) | MAT2AKIF11ESR1MAPK1 | |
| SCHEMBL20983234 | 0.86 | MAT2A (0.58) | MAT2ANPC1DHODHESR1 | |
| SCHEMBL8532964 | 0.85 | MAT2A (0.52) | MAT2ACTSVCTSLKIF11NPC1 | |
| SCHEMBL20983232 | 0.85 | MAT2A (0.55) | MAT2AKIF11GPR84NPC1ESR1 | |
| SCHEMBL8515688 | 0.85 | MAT2A (0.55) | MAT2AKIF11ESR1 | |
| SCHEMBL8535303 | 0.85 | MAT2A (0.55) | MAT2AKIF11CNR1 | |
| SCHEMBL8535958 | 0.82 | MAT2A (0.59) | MAT2ACCNT1CCNE1CDK2CDK9 | |
| SCHEMBL29382545 | 0.82 | MAT2A (0.42) | MAT2ABCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | claimed |
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |