Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 1/20 | 0.52 |
| ▸ | KIF11 | P52732 | 3/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | CTSV | O60911 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8515371 | 0.92 | MAT2A (0.56) | MAT2AKIF11CYP2D6MAPTKMT2A | |
| SCHEMBL8537794 | 0.90 | MAT2A (0.50) | MAT2AKIF11SLC6A4CYP2D6MAPT | |
| SCHEMBL8533470 | 0.89 | MAT2A (0.54) | MAT2AKIF11CYP2D6MAPTKMT2A | |
| SCHEMBL29505903 | 0.89 | MAT2A (0.54) | MAT2AKIF11CYP2D6MAPTKMT2A | |
| SCHEMBL8533461 | 0.87 | MAT2A (0.56) | MAT2AKIF11KMT2AESR1 | |
| SCHEMBL20983234 | 0.87 | MAT2A (0.58) | MAT2AMAPTESR1ABCG2NPC1 | |
| SCHEMBL8537609 | 0.86 | KIF11 (0.44) | MAT2AKIF11SLC6A4MAPTKMT2A | |
| SCHEMBL8535303 | 0.86 | MAT2A (0.55) | MAT2AKIF11SLC6A4 | |
| SCHEMBL20983232 | 0.86 | MAT2A (0.55) | MAT2AKIF11ESR1NPC1AR | |
| SCHEMBL8515688 | 0.86 | MAT2A (0.55) | MAT2AKIF11MAPTESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10799494-B2 | Combination of respiratory electron transport chain inhibitors with a cytochrome bd inhibitor | LIVERPOOL SCHOOL TROPICAL MEDICINE (GB) | 2020-10-13 | — | — | US | claimed |
| US-20190151305-A1 | COMBINATION PRODUCT | LIVERPOOL SCHOOL TROPICAL MEDICINE (GB) | 2019-05-23 | — | — | US | claimed |
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | claimed |
| US-10799494-B2 | Combination of respiratory electron transport chain inhibitors with a cytochrome bd inhibitor | LIVERPOOL SCHOOL TROPICAL MEDICINE (GB) | 2020-10-13 | — | — | US | disclosed |
| US-10799494-B2 | Combination of respiratory electron transport chain inhibitors with a cytochrome bd inhibitor | LIVERPOOL SCHOOL TROPICAL MEDICINE (GB) | 2020-10-13 | — | — | US | disclosed |
| US-20190151305-A1 | COMBINATION PRODUCT | LIVERPOOL SCHOOL TROPICAL MEDICINE (GB) | 2019-05-23 | — | — | US | disclosed |
| US-20190151305-A1 | COMBINATION PRODUCT | LIVERPOOL SCHOOL TROPICAL MEDICINE (GB) | 2019-05-23 | — | — | US | disclosed |
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10799494-B2 | Combination of respiratory electron transport chain inhibitors with a cytochrome bd inhibitor | NDUFB7, NDUFB3, NDUFB5 | MAT2A 3025/4885KIF11 2588/4885SLC6A4 908/4885 |
| US-20190151305-A1 | COMBINATION PRODUCT | NDUFB5, NDUFB7, NDUFB10 | MAT2A 2903/4885KIF11 1969/4885SLC6A4 725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.