Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 8/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8540460 | 0.76 | LIPE (0.53) | NAMPT | |
| SCHEMBL8542599 | 0.74 | ATM (0.44) | SMN1; SMN2KDM4EALDH1A1HSD17B10CHRM2 | |
| SCHEMBL8543669 | 0.71 | ALDH1A1 (0.51) | SMN1; SMN2KDM4EALDH1A1HSD17B10CNR2 | |
| SCHEMBL8544484 | 0.69 | CHRM2 (0.41) | SMN1; SMN2KDM4EALDH1A1HSD17B10CHRM2 | |
| SCHEMBL8539645 | 0.69 | ALDH1A1 (0.50) | SMN1; SMN2KDM4EALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL8538321 | 0.68 | RXFP1 (0.48) | SMN1; SMN2KDM4EALDH1A1HSD17B10CHRM2 | |
| SCHEMBL8540839 | 0.68 | ALDH1A1 (0.45) | SMN1; SMN2KDM4EALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL9289082 | 0.67 | SMN1; SMN2 (0.50) | SMN1; SMN2KDM4EALDH1A1L3MBTL1MAPT | |
| SCHEMBL8589735 | 0.67 | CHRM2 (0.42) | SMN1; SMN2KDM4EALDH1A1HSD17B10CHRM2 | |
| SCHEMBL8544896 | 0.66 | SMN1; SMN2 (0.49) | SMN1; SMN2KDM4EALDH1A1HSD17B10CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0671388-B1 | (Pyrrolidinyl)phenyl carbamates and intermediate compounds, processes for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1998-06-10 | — | — | EP | claimed |