SCHEMBL8538684

SCHEMBL8538684

c1ccc(C(c2ccncc2)c2cccs2)cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 4/20 0.63
SLC6A4 P31645 4/20 0.63
SLC6A3 Q01959 4/20 0.63
MAPT P10636 4/20 0.50
AHR P35869 1/20 0.50
TSHR P16473 1/20 0.49
TP53 P04637 1/20 0.43
CFTR P13569 1/20 0.42
GOPC Q9HD26 1/20 0.42
CNR1 P21554 1/20 0.42
RBP1 P09455 1/20 0.41
HSD17B10 Q99714 1/20 0.41
CYP19A1 P11511 1/20 0.39
ALDH1A1 P00352 1/20 0.38
PKM P14618 1/20 0.38
HPGD P15428 1/20 0.38
HTT P42858 1/20 0.38
ATM Q13315 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1537396 0.90 MAPT (0.57) SLC6A2SLC6A4SLC6A3MAPTAHR
SCHEMBL28734597 0.86 MAPT (0.53) SLC6A2SLC6A4SLC6A3MAPTAHR
SCHEMBL31065464 0.86 MAPT (0.57) SLC6A2SLC6A4SLC6A3MAPTAHR
SCHEMBL29064056 0.79 CNR1 (0.53) SLC6A2SLC6A4SLC6A3MAPTAHR
SCHEMBL733008 0.79 SLC6A3 (1.00) SLC6A2SLC6A4SLC6A3MAPTCFTR
Ammonia Solution, Strong SCHEMBL5999715 0.77 SLC6A3 (0.95) SLC6A2SLC6A4SLC6A3MAPTCFTR
Diethylamine SCHEMBL11328224 0.77 MAPT (0.47) SLC6A2SLC6A4SLC6A3MAPTAHR
SCHEMBL2433699 0.75 ACP3 (0.46) SLC6A4SLC6A3MAPTAHRTP53
SCHEMBL28628674 0.74 TSHR (0.46) SLC6A2SLC6A4SLC6A3MAPTAHR
SCHEMBL15004363 0.74 TSHR (0.69) SLC6A2SLC6A4SLC6A3MAPTAHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5827501-A INERT TRIARYLMETHYL FREE RADICAL CONTRAST AGENTS FOR ELECTRON SPIN RESONANCE (ESR) ENHANCED MAGNETIC RESONANCE (EMR) IMAGING NYCOMED IMAGING AS (NO) 1998-10-27 US disclosed
US-5599522-A CONTRAST ENHANCING AGENTS NYCOMED IMAGING AS (NO) 1997-02-04 US disclosed
EP-0515458-B1 TRIARYLMETHYL RADICALS AND THE USE OF INERT CARBON FREE RADICALS IN MRI NYCOMED INNOVATION AB (SE) 1995-08-23 EP disclosed
EP-0515458-A1 TRIARYLMETHYL RADICALS AND THE USE OF INERT CARBON FREE RADICALS IN MRI. HAFSLUND NYCOMED INNOVATION (SE) 1992-12-02 EP disclosed
WO-1991012024-A1 TRIARYLMETHYL RADICALS AND THE USE OF INERT CARBON FREE RADICALS IN MRI HAFSLUND NYCOMED INNOVATION AB (SE) 1991-08-22 WO disclosed