Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL311252 | 1.00 | TP53 (0.49) | TP53TSHRPKMAPEX1CYP2C19 | |
| SCHEMBL3373627 | 0.80 | HRH3 (0.42) | TP53TSHRCYP2C19CYP2D6RAB9A | |
| SCHEMBL12536783 | 0.79 | TSHR (0.79) | TP53TSHRPKMAPEX1CYP2C19 | |
| SCHEMBL6309997 | 0.77 | TP53 (0.68) | TP53TSHRPKMAPEX1CYP2C19 | |
| SCHEMBL72682 | 0.77 | TP53 (0.68) | TP53TSHRPKMAPEX1CYP2C19 | |
| SCHEMBL57818 | 0.77 | TP53 (0.68) | TP53TSHRPKMAPEX1CYP2C19 | |
| SCHEMBL883098 | 0.77 | TP53 (0.68) | TP53TSHRPKMAPEX1CYP2C19 | |
| SCHEMBL72171 | 0.77 | TP53 (0.68) | TP53TSHRPKMAPEX1CYP2C19 | |
| SCHEMBL938198 | 0.77 | TP53 (0.68) | TP53TSHRPKMAPEX1CYP2C19 | |
| SCHEMBL29777001 | 0.77 | TP53 (0.68) | TP53TSHRPKMAPEX1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0720609-B1 | 3-(5-TETRAZOLYL-BENZYL)AMINO-PIPERIDINE DERIVATIVES AND ANTAGONISTS OF TACHYKININS | GLAXO GROUP LTD (GB) | 1998-11-11 | — | — | EP | disclosed |